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C1F510

- ASSY_ACIC5

UniProt

C1F510 - ASSY_ACIC5

Protein

Argininosuccinate synthase

Gene

argG

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPUniRule annotation
    Binding sitei99 – 991CitrullineUniRule annotation
    Binding sitei129 – 1291ATP; via amide nitrogenUniRule annotation
    Binding sitei131 – 1311AspartateUniRule annotation
    Binding sitei131 – 1311ATPUniRule annotation
    Binding sitei135 – 1351AspartateUniRule annotation
    Binding sitei135 – 1351CitrullineUniRule annotation
    Binding sitei136 – 1361AspartateUniRule annotation
    Binding sitei136 – 1361ATPUniRule annotation
    Binding sitei139 – 1391CitrullineUniRule annotation
    Binding sitei192 – 1921CitrullineUniRule annotation
    Binding sitei194 – 1941ATPUniRule annotation
    Binding sitei201 – 2011CitrullineUniRule annotation
    Binding sitei203 – 2031CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACAP240015:GKF4-3041-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:ACP_3096
    OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
    Taxonomic identifieri240015 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
    ProteomesiUP000002207: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Argininosuccinate synthasePRO_1000146927Add
    BLAST

    Proteomic databases

    PRIDEiC1F510.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi240015.ACP_3096.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1F510-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVILEHLPT GQKVGIAFSG GLDTSAALHW MKQKGALPYA YTANLGQPDE    50
    TDYEAIPRKA LEYGAEIARL IDCREPLVRE GIAALQSGAF HITTAGVTYF 100
    NTTPIGRAVT GTMLVTAMKE DDVNIWGDGS TFKGNDIERF YRYGLLVNPD 150
    LKVYKPWLDS AFIDELGGRA EMSEFLQKSG FDYKMSAEKA YSTDSNILGA 200
    THEAKDLELL SSSIRIVQPI MGVAFWRDDV AVKAEEVTVR FEEGFPVALN 250
    GTTYADPVEL MLEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
    FAAYERLITG IHNEDTIEQY HENGRKLGRL LYQGRWFDSQ AIMLRESAQR 350
    WVARPITGEV TLELRRGNDY SILNTDSPNL TFKPERLTME KGESTFSPRD 400
    RIGQLTMRNL DITDTREKLL TYAKSGLITL SHGSELPKLN SGEKN 445
    Length:445
    Mass (Da):49,594
    Last modified:May 26, 2009 - v1
    Checksum:i8B09620501F13288
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO33563.1.
    RefSeqiYP_002756105.1. NC_012483.1.

    Genome annotation databases

    EnsemblBacteriaiACO33563; ACO33563; ACP_3096.
    GeneIDi7700731.
    KEGGiaca:ACP_3096.
    PATRICi20669411. VBIAciCap40988_2964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO33563.1 .
    RefSeqi YP_002756105.1. NC_012483.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240015.ACP_3096.

    Proteomic databases

    PRIDEi C1F510.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO33563 ; ACO33563 ; ACP_3096 .
    GeneIDi 7700731.
    KEGGi aca:ACP_3096.
    PATRICi 20669411. VBIAciCap40988_2964.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci ACAP240015:GKF4-3041-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51196 / DSM 11244 / JCM 7670.

    Entry informationi

    Entry nameiASSY_ACIC5
    AccessioniPrimary (citable) accession number: C1F510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3