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C1F461

- MRAY_ACIC5

UniProt

C1F461 - MRAY_ACIC5

Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

    Catalytic activityi

    UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciACAP240015:GKF4-1067-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
    Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
    Gene namesi
    Name:mraYUniRule annotation
    Ordered Locus Names:ACP_1089
    OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
    Taxonomic identifieri240015 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
    ProteomesiUP000002207: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Phospho-N-acetylmuramoyl-pentapeptide-transferasePRO_1000117153Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi240015.ACP_1089.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalUniRule annotationAdd
    BLAST
    Transmembranei71 – 9121HelicalUniRule annotationAdd
    BLAST
    Transmembranei94 – 11421HelicalUniRule annotationAdd
    BLAST
    Transmembranei139 – 15921HelicalUniRule annotationAdd
    BLAST
    Transmembranei182 – 20221HelicalUniRule annotationAdd
    BLAST
    Transmembranei216 – 23621HelicalUniRule annotationAdd
    BLAST
    Transmembranei252 – 27221HelicalUniRule annotationAdd
    BLAST
    Transmembranei280 – 30021HelicalUniRule annotationAdd
    BLAST
    Transmembranei305 – 32521HelicalUniRule annotationAdd
    BLAST
    Transmembranei354 – 37421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0472.
    HOGENOMiHOG000275122.
    KOiK01000.
    OMAiQIHYVSG.
    OrthoDBiEOG69GZPZ.

    Family and domain databases

    HAMAPiMF_00038. MraY.
    InterProiIPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view]
    PANTHERiPTHR22926. PTHR22926. 1 hit.
    PfamiPF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00445. mraY. 1 hit.
    PROSITEiPS01348. MRAY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1F461-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLYWLLYQKL FPYFRPFRIF RYLTFRTAFA SLTALLIALL IGPYVIEKLR    50
    EFQIGQYIRE EGPQAHQKKA GTPTMGGVLI CIAILLPTLL WSDLSDPFVW 100
    IVMLSTLAFG AIGFADDYIK VVHRRNLGLT ARAKMTYQIL ASAAIGVALV 150
    VLQGQGSYST DLMVPFAKSL RPRFSIPALL HVPHLAYFAF IPFVIFVIIV 200
    IVGSSNAVNL TDGLDGLAIG CTIIAAGALT VLTYVSGHAV FADYLELQRM 250
    PMVGEVTIFC GAMVGASIGF LWYNAHPAQI FMGDVGSLAL GGAIATVAVV 300
    IKQELLLPFI GGIFVLEALS VILQVGSYKL RKKRIFKMAP LHHHFELIGW 350
    SESKVIVRFW IAALVFALFA LTTLKLR 377
    Length:377
    Mass (Da):41,561
    Last modified:May 26, 2009 - v1
    Checksum:i093E49E93231F4A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO32749.1.
    RefSeqiWP_015896247.1. NC_012483.1.
    YP_002754194.1. NC_012483.1.

    Genome annotation databases

    EnsemblBacteriaiACO32749; ACO32749; ACP_1089.
    GeneIDi7701016.
    KEGGiaca:ACP_1089.
    PATRICi20665531. VBIAciCap40988_1057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO32749.1 .
    RefSeqi WP_015896247.1. NC_012483.1.
    YP_002754194.1. NC_012483.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240015.ACP_1089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO32749 ; ACO32749 ; ACP_1089 .
    GeneIDi 7701016.
    KEGGi aca:ACP_1089.
    PATRICi 20665531. VBIAciCap40988_1057.

    Phylogenomic databases

    eggNOGi COG0472.
    HOGENOMi HOG000275122.
    KOi K01000.
    OMAi QIHYVSG.
    OrthoDBi EOG69GZPZ.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci ACAP240015:GKF4-1067-MONOMER.

    Family and domain databases

    HAMAPi MF_00038. MraY.
    InterProi IPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view ]
    PANTHERi PTHR22926. PTHR22926. 1 hit.
    Pfami PF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00445. mraY. 1 hit.
    PROSITEi PS01348. MRAY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51196 / DSM 11244 / JCM 7670.

    Entry informationi

    Entry nameiMRAY_ACIC5
    AccessioniPrimary (citable) accession number: C1F461
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3