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C1F461

- MRAY_ACIC5

UniProt

C1F461 - MRAY_ACIC5

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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciACAP240015:GKF4-1067-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:ACP_1089
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
ProteomesiUP000002207: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Phospho-N-acetylmuramoyl-pentapeptide-transferasePRO_1000117153Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240015.ACP_1089.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721HelicalUniRule annotationAdd
BLAST
Transmembranei71 – 9121HelicalUniRule annotationAdd
BLAST
Transmembranei94 – 11421HelicalUniRule annotationAdd
BLAST
Transmembranei139 – 15921HelicalUniRule annotationAdd
BLAST
Transmembranei182 – 20221HelicalUniRule annotationAdd
BLAST
Transmembranei216 – 23621HelicalUniRule annotationAdd
BLAST
Transmembranei252 – 27221HelicalUniRule annotationAdd
BLAST
Transmembranei280 – 30021HelicalUniRule annotationAdd
BLAST
Transmembranei305 – 32521HelicalUniRule annotationAdd
BLAST
Transmembranei354 – 37421HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0472.
HOGENOMiHOG000275122.
KOiK01000.
OMAiQIHYVSG.
OrthoDBiEOG69GZPZ.

Family and domain databases

HAMAPiMF_00038. MraY.
InterProiIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiPS01348. MRAY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1F461-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYWLLYQKL FPYFRPFRIF RYLTFRTAFA SLTALLIALL IGPYVIEKLR
60 70 80 90 100
EFQIGQYIRE EGPQAHQKKA GTPTMGGVLI CIAILLPTLL WSDLSDPFVW
110 120 130 140 150
IVMLSTLAFG AIGFADDYIK VVHRRNLGLT ARAKMTYQIL ASAAIGVALV
160 170 180 190 200
VLQGQGSYST DLMVPFAKSL RPRFSIPALL HVPHLAYFAF IPFVIFVIIV
210 220 230 240 250
IVGSSNAVNL TDGLDGLAIG CTIIAAGALT VLTYVSGHAV FADYLELQRM
260 270 280 290 300
PMVGEVTIFC GAMVGASIGF LWYNAHPAQI FMGDVGSLAL GGAIATVAVV
310 320 330 340 350
IKQELLLPFI GGIFVLEALS VILQVGSYKL RKKRIFKMAP LHHHFELIGW
360 370
SESKVIVRFW IAALVFALFA LTTLKLR
Length:377
Mass (Da):41,561
Last modified:May 26, 2009 - v1
Checksum:i093E49E93231F4A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO32749.1.
RefSeqiWP_015896247.1. NC_012483.1.
YP_002754194.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO32749; ACO32749; ACP_1089.
GeneIDi7701016.
KEGGiaca:ACP_1089.
PATRICi20665531. VBIAciCap40988_1057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO32749.1 .
RefSeqi WP_015896247.1. NC_012483.1.
YP_002754194.1. NC_012483.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240015.ACP_1089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO32749 ; ACO32749 ; ACP_1089 .
GeneIDi 7701016.
KEGGi aca:ACP_1089.
PATRICi 20665531. VBIAciCap40988_1057.

Phylogenomic databases

eggNOGi COG0472.
HOGENOMi HOG000275122.
KOi K01000.
OMAi QIHYVSG.
OrthoDBi EOG69GZPZ.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci ACAP240015:GKF4-1067-MONOMER.

Family and domain databases

HAMAPi MF_00038. MraY.
InterProi IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view ]
PANTHERi PTHR22926. PTHR22926. 1 hit.
Pfami PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00445. mraY. 1 hit.
PROSITEi PS01348. MRAY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Entry informationi

Entry nameiMRAY_ACIC5
AccessioniPrimary (citable) accession number: C1F461
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3