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C1F461 (MRAY_ACIC5) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase

EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:ACP_1089
OrganismAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]
Taxonomic identifier240015 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_1000117153

Regions

Transmembrane27 – 4721Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane139 – 15921Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane252 – 27221Helical; Potential
Transmembrane280 – 30021Helical; Potential
Transmembrane305 – 32521Helical; Potential
Transmembrane354 – 37421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
C1F461 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 093E49E93231F4A7

FASTA37741,561
        10         20         30         40         50         60 
MLYWLLYQKL FPYFRPFRIF RYLTFRTAFA SLTALLIALL IGPYVIEKLR EFQIGQYIRE 

        70         80         90        100        110        120 
EGPQAHQKKA GTPTMGGVLI CIAILLPTLL WSDLSDPFVW IVMLSTLAFG AIGFADDYIK 

       130        140        150        160        170        180 
VVHRRNLGLT ARAKMTYQIL ASAAIGVALV VLQGQGSYST DLMVPFAKSL RPRFSIPALL 

       190        200        210        220        230        240 
HVPHLAYFAF IPFVIFVIIV IVGSSNAVNL TDGLDGLAIG CTIIAAGALT VLTYVSGHAV 

       250        260        270        280        290        300 
FADYLELQRM PMVGEVTIFC GAMVGASIGF LWYNAHPAQI FMGDVGSLAL GGAIATVAVV 

       310        320        330        340        350        360 
IKQELLLPFI GGIFVLEALS VILQVGSYKL RKKRIFKMAP LHHHFELIGW SESKVIVRFW 

       370 
IAALVFALFA LTTLKLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001472 Genomic DNA. Translation: ACO32749.1.
RefSeqYP_002754194.1. NC_012483.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240015.ACP_1089.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO32749; ACO32749; ACP_1089.
GeneID7701016.
KEGGaca:ACP_1089.
PATRIC20665531. VBIAciCap40988_1057.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHOG000275122.
KOK01000.
OMAQIHYVSG.
OrthoDBEOG69GZPZ.

Enzyme and pathway databases

BioCycACAP240015:GKF4-1067-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACIC5
AccessionPrimary (citable) accession number: C1F461
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways