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C1F3Y6 (C1F3Y6_ACIC5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172 EMBL ACO33349.1
Ordered Locus Names:ACP_2931
OrganismAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]
Taxonomic identifier240015 [NCBI]
Taxonomic lineageBacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length758 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6431Zinc By similarity HAMAP MF_00172
Metal binding6451Zinc By similarity HAMAP MF_00172
Metal binding7281Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
C1F3Y6 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 6A1011CB7E7678DC

FASTA75884,496
        10         20         30         40         50         60 
MATDEASTSL SLKTANLGFP RMGQQRELKF ALEDYWTGKC TEEQLQNVAG QLRQSHWELQ 

        70         80         90        100        110        120 
KTAGIDFIPS NDFSLYDQVL DMLVLLGATP ERFGTDTVTL PRYFAMARNS REQTAMEMTK 

       130        140        150        160        170        180 
WFDTNYHYLV PEWSEGLSFK INSAKLLGEV REARALGIET RPVLIGPLTL LLLGKGVDAF 

       190        200        210        220        230        240 
DPFTVTDRLI PAYQAVLAEL AAENVEWVQM DEPILATDLP EGAAEIFRKA YAAFALSPVK 

       250        260        270        280        290        300 
LMLTTYFERL GDNLPLAIAA HTAGLHVDAV RAPEQIEEVI DALHPDQVLS VGCVDGRNIW 

       310        320        330        340        350        360 
LTDFSAADAM LRQAARKLGQ ARVIAAPSCS LLHVPHTLRG ETQLPARMRG WLRFAEEKLA 

       370        380        390        400        410        420 
ELTALATGDP AAAAENAAAI QDRAAAESST NAAVRAQLHA LKASDFTRSS AYPERARVQR 

       430        440        450        460        470        480 
DQLRLPLFPT TTIGSFPQTS EVRKHRAAHK HGHETAGQYE TFLREATAQC IRQQEAIGLD 

       490        500        510        520        530        540 
VLVHGEFERN DMVEYFAEFL EGFAFTQNGW VQSYGSRCVK PPVIFGDVSR PRAMTVEWSR 

       550        560        570        580        590        600 
YAQSLTERPV KGMLTGPITI LQWSFPRNDI PRQQIAWQIA LALRDEVQDL EAAGIRIIQV 

       610        620        630        640        650        660 
DEPALREGLP LRRADWAAYL EWAVQAFRLA TSGVRDETQI HTHMCYCEFE DVLPSIAALD 

       670        680        690        700        710        720 
ADVISMEAAR SRMELLDAFR EHGYPNEIGP GVYDIHSPRV PSVEEMHELL RLAARVLKPG 

       730        740        750 
QLWVNPDCGL KTRKWPETIA ALTNLCAAAE RLREEAGA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001472 Genomic DNA. Translation: ACO33349.1.
RefSeqYP_002755941.1. NC_012483.1.

3D structure databases

ProteinModelPortalC1F3Y6.
ModBaseSearch...

Protein-protein interaction databases

STRINGC1F3Y6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7700318.
GenomeReviewsGene locus ACP_2931 in contig CP001472_GR.
KEGGaca:ACP_2931.
PATRIC20669093. VBIAciCap40988_2805.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1F3Y6_ACIC5
AccessionPrimary (citable) accession number: C1F3Y6
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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