C1F3A8 (C1F3A8_ACIC5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ribonuclease HII HAMAP MF_00052
Short name=RNase HII HAMAP MF_00052
EC=3.1.26.4 HAMAP MF_00052

Gene names

Name:	rnhB HAMAP MF_00052 EMBL ACO34490.1
Ordered Locus Names:	ACP_2802

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]

Taxonomic identifier

240015 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity. RuleBase RU003515 HAMAP MF_00052
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. RuleBase RU003515 HAMAP MF_00052
Cofactor	Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding By similarity. HAMAP MF_00052
Subcellular location	Cytoplasm By similarity HAMAP MF_00052.
Sequence similarities	Belongs to the RNase HII family. RuleBase RU003515 HAMAP MF_00052

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00052
Ligand	Manganese HAMAP MF_00052 Metal-binding HAMAP MF_00052
Molecular function	Endonuclease RuleBase RU003515 HAMAP MF_00052 Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: HAMAP ribonuclease H activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	45	1	Divalent metal cation By similarity HAMAP MF_00052
	Metal binding	46	1	Divalent metal cation By similarity HAMAP MF_00052
	Metal binding	137	1	Divalent metal cation By similarity HAMAP MF_00052

Sequences

	Sequence		Length	Mass (Da)
	C1F3A8 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: D3CE946737D5276E	FASTA	236	25,934
	10 20 30 40 50 60 MPPRSASRSV SPATLKQRML RQLVCGDRYE RQARQQGATA IAGVDEVGRG ALFGPVVAAA 70 80 90 100 110 120 VILPSRIRLE GLRDSKQLRV SDRERLATEV HACAIAVAIA EVDVETIDRI NIYQATRLAM 130 140 150 160 170 180 LRAVELLQPE PDHLLIDAMR IDHPCAQTSI IYGDSLSLSI AAASVVAKVY RDRLVCELHA 190 200 210 220 230 LYPEYGLDAH KGYGTPRHKA ALLQYGPTPL HRKSFAPVTQ SELFLNEESS AQESMI

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001472 Genomic DNA. Translation: ACO34490.1.
RefSeq	YP_002755820.1. NC_012483.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C1F3A8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7700616.
GenomeReviews	Gene locus ACP_2802 in contig CP001472_GR.
KEGG	aca:ACP_2802.
PATRIC	20668843. VBIAciCap40988_2685.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RLGPTPI.
ProtClustDB	CLSK774867.
Family and domain databases
HAMAP	MF_00052_B. RNase_HII_B. [Tree]
InterPro	IPR022898. RNase_HII. IPR001352. RNase_HII/HIII. IPR024567. RNase_HII/HIII_dom. IPR012337. RNaseH-like_dom. [Graphical view]
KO	K03470.
PANTHER	PTHR10954. RNase_HII/HIII. 1 hit.
Pfam	PF01351. RNase_HII. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C1F3A8_ACIC5

Accession

Primary (citable) accession number: C1F3A8

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)