ID   C1F2M5_ACIC5            Unreviewed;       463 AA.
AC   C1F2M5;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Uronate isomerase {ECO:0000256|ARBA:ARBA00020555, ECO:0000256|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000256|ARBA:ARBA00012546, ECO:0000256|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000256|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000256|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000256|HAMAP-Rule:MF_00675,
GN   ECO:0000313|EMBL:ACO31794.1};
GN   OrderedLocusNames=ACP_2685 {ECO:0000313|EMBL:ACO31794.1};
OS   Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM
OS   7670 / NBRC 15755 / NCIMB 13165 / 161).
OC   Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC   Acidobacterium.
OX   NCBI_TaxID=240015 {ECO:0000313|EMBL:ACO31794.1, ECO:0000313|Proteomes:UP000002207};
RN   [1] {ECO:0000313|EMBL:ACO31794.1, ECO:0000313|Proteomes:UP000002207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 /
RC   NCIMB 13165 / 161 {ECO:0000313|Proteomes:UP000002207};
RX   PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001165, ECO:0000256|HAMAP-
CC         Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000256|ARBA:ARBA00004892, ECO:0000256|HAMAP-
CC       Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000256|ARBA:ARBA00008397,
CC       ECO:0000256|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001472; ACO31794.1; -; Genomic_DNA.
DR   RefSeq; WP_015897749.1; NC_012483.1.
DR   AlphaFoldDB; C1F2M5; -.
DR   STRING; 240015.ACP_2685; -.
DR   KEGG; aca:ACP_2685; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_0; -.
DR   InParanoid; C1F2M5; -.
DR   OrthoDB; 9766564at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002207; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 1.10.2020.10; uronate isomerase, domain 2, chain A; 1.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   PANTHER; PTHR30068; URONATE ISOMERASE; 1.
DR   PANTHER; PTHR30068:SF4; URONATE ISOMERASE; 1.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00675};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002207}.
SQ   SEQUENCE   463 AA;  52627 MW;  58A556B193228BEF CRC64;
     MLMHEDRLFP ADPTTRRIAR SLYEQVRSLP IVSPHGHTQA AWFAHNEPFP DPAKLFVQPD
     HYIYRMLYSQ GVTLEDLEIG VEQIQNPRKV WRIFASHYYL FRGTPTRLWL DFAFETLFGL
     TESLSAKTSD LYFDTISEKL QTPEFRPRAL YERFHLEVLA TTDSPLDSLA DHQIIRDSGW
     PARILATFRP DSVVDPDFTG FADNIATLGA QTGEDTAHWS GYLKALRQAR ARFRSLGATA
     TDHGHPTAQT ANLSEPEAAQ LFITVLSGNA TAAQRELFRA QMLTEMARMS VEDGLVMQIH
     PGSARNHNRK LYERYGRDVG ADIPMPTNYV DALRPMLDLV GNERGLTIIL FTLDETAYSR
     ELAPLAGHYP CLRLGPPWWF HDSPEGMMRF REQVTETAGF YNTVGFNDDT RAFLSIPARH
     DVARRIDCAF LARLVAEHRL SEEEAAEVAH DLAYKLVKAA YRL
//