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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei360ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 80ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation
Biological processStress responseImported
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotationImported
Ordered Locus Names:ACP_2657Imported
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)Imported
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
Proteomesi
  • UP000002207 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi240015.ACP_2657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 371AAAInterPro annotationAdd BLAST308
Domaini374 – 465ClpB_D2-smallInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C4N. Bacteria.
COG1220. LUCA.
HOGENOMiHOG000010036.
KOiK03667.
OMAiKYGMIKT.
OrthoDBiPOG091H01U4.

Family and domain databases

HAMAPiMF_00249. HslU. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR011704. ATPase_dyneun-rel_AAA.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
PANTHERiPTHR43815. PTHR43815. 1 hit.
PfamiView protein in Pfam
PF07724. AAA_2. 1 hit.
PF07728. AAA_5. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00390. hslU. 1 hit.

Sequencei

Sequence statusi: Complete.

C1F2J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIYLPGTAE DQELALDELT PREIVGELDK YVVGQKAAKR AVAIALRNRM
60 70 80 90 100
RRQKLTPDLA DEIMPKNIIM IGPTGVGKTE IARRLAKLTN SPFLKVEASK
110 120 130 140 150
FTEVGYVGRD VESMVRDLVE IAIDMVREEK LEEVEDKAEL NAEERLLDLL
160 170 180 190 200
LPPPATQTPA AAPAGAGETP DAHGAIILPP PAASATQESQ QRTREKLRQQ
210 220 230 240 250
FREGKLDDRM VELDVRERGA PSFEIISNQG VEEMDINLKD VLPSIFGQRT
260 270 280 290 300
KKRKMKVAEA FEYLVQEEES RLIDMDQVTR AAVERVETSG IVFLDEIDKI
310 320 330 340 350
AGREGGHGPD VSREGVQRDI LPIVEGTTVN TRYGMVRTDY ILFIAAGAFH
360 370 380 390 400
VSKPSDLIPE LQGRFPIRVE LQSLTVEDFI RILTEPKSSL VKQSTALLET
410 420 430 440 450
EGLKLEFTPE AIAEMAQFAF SVNETTENIG ARRLHTIMEK VLDDISFLAP
460 470 480 490 500
DLIKHGKGKS EAGVVDLAAA ANGHAEMAPI APLPVIERET PGGTELVAVV
510 520
DPEYVKQMVA SIVKNQDLSR YIL
Length:523
Mass (Da):57,741
Last modified:May 26, 2009 - v1
Checksum:iA7A1726F9AD82705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA. Translation: ACO32421.1.
RefSeqiWP_015897722.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO32421; ACO32421; ACP_2657.
KEGGiaca:ACP_2657.

Similar proteinsi

Entry informationi

Entry nameiC1F2J7_ACIC5
AccessioniPrimary (citable) accession number: C1F2J7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported