C1F273 (C1F273_ACIC5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543 EMBL ACO33325.1
Ordered Locus Names:	ACP_0733

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]

Taxonomic identifier

240015 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length	537 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ACO33325.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	57 – 64	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	C1F273 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 0A33C4ABFCD1E7A0	FASTA	537	56,883
	10 20 30 40 50 60 MPDNLLPIDS IARKLNLPED AYEPLGRHGA KVKLDLLANP AFPRRGKLIL VTATSPTTSG 70 80 90 100 110 120 EGKTVTSIGL TQGLERIGKK VLITSREPSL GPVFGMKGGA AGGGRSQIEP SQKINLHFHG 130 140 150 160 170 180 DLHAITSAHN LLAALIDAHL FHGNDLGLDP ERITWPRAMD MNDRALRRIV ISAGGKREGA 190 200 210 220 230 240 NRSTGFVITA ASEVMAIMAL AQNRDDLRQR LDRIVIGQNK SGEPVTAAAL DATGAMMALL 250 260 270 280 290 300 ADALLPNLVQ TTEGTPAFVH CGPFGNIAHG TSSVVSQQMA LRLADYVVNE AGFAADLGAE 310 320 330 340 350 360 KYIDIVMRSS GIAPSAAVVV TTVQSMRNQG EGDLERGLPN LARHIQNMRN FGLPIVVAIN 370 380 390 400 410 420 RFPSDTDTDL ERLAEFAQQH GAESAYSEAF TRGGEGAVAL AEKVVAALEK HPNVTVTPAY 430 440 450 460 470 480 ALEDSLEEKV RKVAAQIYGA DGVEFSEAAQ AKLKQFTAWG YADLPVCIAK TQYSFSDNPK 490 500 510 520 530 LLGAPTGWTL HITDAALSAG AGFVVMIAGN MMLMPGLPKV SRAAEIDVNA EGVITGI

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001472 Genomic DNA. Translation: ACO33325.1.
RefSeq	YP_002753851.1. NC_012483.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C1F273.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7700991.
GenomeReviews	Gene locus ACP_0733 in contig CP001472_GR.
KEGG	aca:ACP_0733.
PATRIC	20664825. VBIAciCap40988_0707.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TDFTVTI.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C1F273_ACIC5

Accession

Primary (citable) accession number: C1F273

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)