Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD kinase

Gene

nadK

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Binding sitei153NADUniRule annotation1
Binding sitei170NADUniRule annotation1
Binding sitei172NADUniRule annotation1
Binding sitei242NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 69NADUniRule annotation2
Nucleotide bindingi142 – 143NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciACAP240015:G1GV4-656-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:ACP_0680
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
Proteomesi
  • UP000002207 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001335561 – 285NAD kinaseAdd BLAST285

Proteomic databases

PRIDEiC1F1S2

Interactioni

Protein-protein interaction databases

STRINGi240015.ACP_0680

Structurei

3D structure databases

SMRiC1F1S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

C1F1S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRIAVIAKP QKDELASLLP ELLAWLHGHG YDPVIDDIAA TYTSEARIVP
60 70 80 90 100
RADLPNENPE LVIVLGGDGT LLAAARVFAK TGVPILSVNL GSLGFLTEVP
110 120 130 140 150
LGDLYRHLEG WAQNCCNIEQ RAMLHCELRR DGHQVCEYEA LNDVVVSKGA
160 170 180 190 200
IARMGDFRID LDGALVAAFR ADGVIISTPT GSTAYSLAAN GPILAPNVDA
210 220 230 240 250
LIVTPVCPHL LTLRPLVVQG NADLKLKVAG IPDQTYLTVD GQEAIALCVG
260 270 280
DEIHCRKSVY TVKLVRLGST GFFDVLRAKL KWGER
Length:285
Mass (Da):30,749
Last modified:May 26, 2009 - v1
Checksum:i87EB0A5245095412
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA Translation: ACO32179.1
RefSeqiWP_015895856.1, NC_012483.1

Genome annotation databases

EnsemblBacteriaiACO32179; ACO32179; ACP_0680
KEGGiaca:ACP_0680

Similar proteinsi

Entry informationi

Entry nameiNADK_ACIC5
AccessioniPrimary (citable) accession number: C1F1S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health