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C1F130 (RUVC_ACIC5) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:ACP_0531
OrganismAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]
Taxonomic identifier240015 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 171171Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_1000195227

Sites

Metal binding71Magnesium By similarity
Metal binding741Magnesium By similarity
Metal binding1471Magnesium By similarity
Metal binding1501Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
C1F130 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: D5A939300A9CB167

FASTA17118,310
        10         20         30         40         50         60 
MRIFGIDCGS EITGYGIVEC PDGTPRSGQP DLRLIAFGGI RPAKKLTLAE RLAFVHRELL 

        70         80         90        100        110        120 
TQLAAHQPDL VAVEEVFYSV NAKSALKLGH VRGVALLAAA TAGLPIAEYA PLTIKSTVTG 

       130        140        150        160        170 
YGLAQKEQVQ FMVARLLHMP EPPEPADAAD ALAIAICHIH HAQTIQAQQS R 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001472 Genomic DNA. Translation: ACO32017.1.
RefSeqYP_002753664.1. NC_012483.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240015.ACP_0531.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO32017; ACO32017; ACP_0531.
GeneID7700519.
KEGGaca:ACP_0531.
PATRIC20664431. VBIAciCap40988_0512.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012182.
KOK01159.
OMAILHMIKL.
OrthoDBEOG6RG044.
ProtClustDBCLSK775008.

Enzyme and pathway databases

BioCycACAP240015:GKF4-522-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
PROSITEPS01321. RUVC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRUVC_ACIC5
AccessionPrimary (citable) accession number: C1F130
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families