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C1ERU9

- GCSPA_BACC3

UniProt

C1ERU9 - GCSPA_BACC3

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Bacillus cereus (strain 03BB102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciBCER572264:GH22-4271-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:BCA_4335
    OrganismiBacillus cereus (strain 03BB102)
    Taxonomic identifieri572264 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002210: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147977Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi572264.BCA_4335.

    Structurei

    3D structure databases

    ProteinModelPortaliC1ERU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1ERU9-1 [UniParc]FASTAAdd to Basket

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    MLHRYLPMTE EDKKEMLQTI GVQTIDELFS DIPESVRFKG DLKIKEAKSE    50
    PELLKELSQM ASKNANLKEY ASFLGAGVYD HYAPVIVDHV ISRSEFYTAY 100
    TPYQPEISQG ELQAIFEFQT MICELTGMDV ANSSMYDGGT ALAEAAMLAA 150
    GHTRKKKILV SSAVHPESRA VLETYAKGQH LEVVEINHKD GVTDLDVLQS 200
    EVDDTVACVI VQYPNFFGQV EKLADIEKIV HQQKSLFIVS SNPLSLGALT 250
    PPGKFGADIV IGDAQPFGIP TQFGGPHCGY FATTKAFMRK IPGRLVGQTV 300
    DSDGKRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKQG 350
    VKEMARQNIS KAQYAKRQFE AKGFTVTFAG PFFNEFVVDC KRPVKEVNDA 400
    LLQKNIIGGY DLGRDYKEHE NHMLVAVTEL RTKEEIDTLV NEMGAIQ 447
    Length:447
    Mass (Da):49,421
    Last modified:May 26, 2009 - v1
    Checksum:i93AAE031125E3A64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001407 Genomic DNA. Translation: ACO30172.1.
    RefSeqiYP_002751586.1. NC_012472.1.

    Genome annotation databases

    EnsemblBacteriaiACO30172; ACO30172; BCA_4335.
    GeneIDi7689703.
    KEGGibcx:BCA_4335.
    PATRICi18821829. VBIBacCer84800_4230.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001407 Genomic DNA. Translation: ACO30172.1 .
    RefSeqi YP_002751586.1. NC_012472.1.

    3D structure databases

    ProteinModelPortali C1ERU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572264.BCA_4335.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO30172 ; ACO30172 ; BCA_4335 .
    GeneIDi 7689703.
    KEGGi bcx:BCA_4335.
    PATRICi 18821829. VBIBacCer84800_4230.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci BCER572264:GH22-4271-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus 03BB102."
      Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 03BB102.

    Entry informationi

    Entry nameiGCSPA_BACC3
    AccessioniPrimary (citable) accession number: C1ERU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3