C1ERQ3 (EX7L_BACC3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exodeoxyribonuclease 7 large subunit
EC=3.1.11.6

Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name=Exonuclease VII large subunit

Gene names

Name:	xseA
Ordered Locus Names:	BCA_4289

Organism

Bacillus cereus (strain 03BB102) [Complete proteome] [HAMAP]

Taxonomic identifier

572264 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus cereus

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00378
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378
Subunit structure	Heterooligomer composed of large and small subunits By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the XseA family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular_function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 452	452	Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378		PRO_1000200659

Sequences

	Sequence		Length	Mass (Da)
	C1ERQ3 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 8C706930F60B724A	FASTA	452	51,440
	10 20 30 40 50 60 MEKQYLTVTA LTRYIKTKIE YDPHLQSVWL KGEISNFKNH SRGHMYFTLK DENARIAAVM 70 80 90 100 110 120 FAGHNRNIKF RPENGMKVLV KGKISVYEAS GSYQIYIQDM QPDGIGNLHL AYEQLKVRLE 130 140 150 160 170 180 EEGLFSQVYK KTIPPYAKTI GVITSPTGAA IRDIITTIKR RYPIGNVIVF PVLVQGESAA 190 200 210 220 230 240 PSIVQAIRTA NEMEEIDVLI VGRGGGSIEE LWAFNEEMVA RAIFKSEIPI ISAVGHETDF 250 260 270 280 290 300 TVADFVADLR APTPTAAAEL AAPNIIELQE KVLQRTLRLQ RAMRELVHKK EEKLQVLQKS 310 320 330 340 350 360 YAFRYPRQVY EQKEEQLDRA LEQLVLAKER YIDKKVNQLK QLSFYLEKHH PSQKIMQTKV 370 380 390 400 410 420 AVETLQKQLQ REMQTLLQTK EFAFVRAAQK LEALSPLKVM MRGYGLVYDE EKQVLKSVKD 430 440 450 VSLGDAVSVQ LQDGILDCSV SGIEERELNN GK

References

[1]	"Genome sequence of Bacillus cereus 03BB102." Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 03BB102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001407 Genomic DNA. Translation: ACO27045.1.
RefSeq	YP_002751540.1. NC_012472.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	572264.BCA_4289.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACO27045; ACO27045; BCA_4289.
GeneID	7688199.
KEGG	bcx:BCA_4289.
PATRIC	18821737. VBIBacCer84800_4184.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1570.
HOGENOM	HOG000229265.
KO	K03601.
OMA	ENAQVRC.
ProtClustDB	PRK00286.
Enzyme and pathway databases
BioCyc	BCER572264:GH22-1406-MONOMER.
Family and domain databases
HAMAP	MF_00378. Exonuc_7_L.
InterPro	IPR003753. Exonuc_VII_L. IPR020579. Exonuc_VII_lsu_C. IPR025824. OB-fold_nuc-bd_dom. [Graphical view]
Pfam	PF02601. Exonuc_VII_L. 1 hit. PF13742. tRNA_anti_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00237. xseA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EX7L_BACC3

Accession

Primary (citable) accession number: C1ERQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program