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C1ERL6

- ACDH_BACC3

UniProt

C1ERL6 - ACDH_BACC3

Protein

Acetaldehyde dehydrogenase

Gene

BCA_2154

Organism
Bacillus cereus (strain 03BB102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261Acyl-thioester intermediateUniRule annotation
    Binding sitei267 – 2671NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi157 – 1659NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBCER572264:GH22-2111-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:BCA_2154
    OrganismiBacillus cereus (strain 03BB102)
    Taxonomic identifieri572264 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002210: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Acetaldehyde dehydrogenasePRO_0000387623Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi572264.BCA_2154.

    Structurei

    3D structure databases

    ProteinModelPortaliC1ERL6.
    SMRiC1ERL6. Positions 2-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiIPEDADH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1ERL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKVKAAIIG SGNIGTDLMY KLRKSEVIDL NAMIGIDVES DGLKRAKEAG    50
    YEVFDNGIQA IIDNPSLADI VFDATSAKAH RYHAKTLEEL EKIVIDLTPA 100
    AYGPFVCPAI RNNNFLDKQN VNMITCGGQA TIPIVHAING VANVTYAEIV 150
    ATISSLSAGP GTRANIDEFT ITTKRGIEEV GGADKGKAII ILNPAEPPIL 200
    MRDTIYCEVK DMDEVSIYEA IHKMVERVRT YVPGYSLKQE PMFDGNRVTV 250
    FLEVEGAGDY FPPYAGNLDI MTAAALKVGE EFATQIISEK KRGVMNEAK 299
    Length:299
    Mass (Da):32,519
    Last modified:May 26, 2009 - v1
    Checksum:i39C5F4B9E090C51D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001407 Genomic DNA. Translation: ACO27046.1.
    RefSeqiYP_002749428.1. NC_012472.1.

    Genome annotation databases

    EnsemblBacteriaiACO27046; ACO27046; BCA_2154.
    GeneIDi7689643.
    KEGGibcx:BCA_2154.
    PATRICi18817429. VBIBacCer84800_2031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001407 Genomic DNA. Translation: ACO27046.1 .
    RefSeqi YP_002749428.1. NC_012472.1.

    3D structure databases

    ProteinModelPortali C1ERL6.
    SMRi C1ERL6. Positions 2-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572264.BCA_2154.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO27046 ; ACO27046 ; BCA_2154 .
    GeneIDi 7689643.
    KEGGi bcx:BCA_2154.
    PATRICi 18817429. VBIBacCer84800_2031.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi IPEDADH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci BCER572264:GH22-2111-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus 03BB102."
      Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 03BB102.

    Entry informationi

    Entry nameiACDH_BACC3
    AccessioniPrimary (citable) accession number: C1ERL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3