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C1ERL6 (ACDH_BACC3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:BCA_2154
OrganismBacillus cereus (strain 03BB102) [Complete proteome] [HAMAP]
Taxonomic identifier572264 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387623

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding157 – 1659NAD By similarity

Sites

Active site1261Acyl-thioester intermediate By similarity
Binding site2671NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
C1ERL6 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 39C5F4B9E090C51D

FASTA29932,519
        10         20         30         40         50         60 
MQKVKAAIIG SGNIGTDLMY KLRKSEVIDL NAMIGIDVES DGLKRAKEAG YEVFDNGIQA 

        70         80         90        100        110        120 
IIDNPSLADI VFDATSAKAH RYHAKTLEEL EKIVIDLTPA AYGPFVCPAI RNNNFLDKQN 

       130        140        150        160        170        180 
VNMITCGGQA TIPIVHAING VANVTYAEIV ATISSLSAGP GTRANIDEFT ITTKRGIEEV 

       190        200        210        220        230        240 
GGADKGKAII ILNPAEPPIL MRDTIYCEVK DMDEVSIYEA IHKMVERVRT YVPGYSLKQE 

       250        260        270        280        290 
PMFDGNRVTV FLEVEGAGDY FPPYAGNLDI MTAAALKVGE EFATQIISEK KRGVMNEAK 

« Hide

References

[1]"Genome sequence of Bacillus cereus 03BB102."
Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 03BB102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001407 Genomic DNA. Translation: ACO27046.1.
RefSeqYP_002749428.1. NC_012472.1.

3D structure databases

ProteinModelPortalC1ERL6.
SMRC1ERL6. Positions 2-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING572264.BCA_2154.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO27046; ACO27046; BCA_2154.
GeneID7689643.
KEGGbcx:BCA_2154.
PATRIC18817429. VBIBacCer84800_2031.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAIPEDADH.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycBCER572264:GH22-2111-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_BACC3
AccessionPrimary (citable) accession number: C1ERL6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families