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C1EPL6 (ILVD_BACC3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase

Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:BCA_1859
OrganismBacillus cereus (strain 03BB102) [Complete proteome] [HAMAP]
Taxonomic identifier572264 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP-Rule MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP-Rule MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP-Rule MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Dihydroxy-acid dehydratase HAMAP-Rule MF_00012
PRO_1000116499

Sites

Metal binding1191Iron-sulfur (4Fe-4S) Potential
Metal binding1921Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
C1EPL6 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 39AACA4DC2C3C30B

FASTA55759,992
        10         20         30         40         50         60 
MRSDMIKKGF DKAPHRSLLK ATGLKDEDFD KPFIAICNSF IEIIPGHKHL NEFGKLVKEA 

        70         80         90        100        110        120 
VRAAGMVPFE FNTIGVDDGI AMGHIGMRYS LPSREIIADS VETVVNAHWF DGMICIPNCD 

       130        140        150        160        170        180 
KITPGMMMAA LRINIPTVFV SGGPMAAGKT SKGDVVDLSS VFEGVGAYQS GKISEEELKD 

       190        200        210        220        230        240 
IEDHGCPSCG SCSGMFTANS MNCLCEVLGL ALPGNGSILA IDPRREELIK QAAEKLKILI 

       250        260        270        280        290        300 
ERDIKPRDIV TEEAIDDAFA LDMAMGGSTN TVLHTLALAQ EAGLDYDMNR IDAVSRRVPH 

       310        320        330        340        350        360 
LCKVSPASNW HMEDIDRAGG ISAILKEMSR KEGVLHLDRI TATGQTLREN IAHAEIKDKE 

       370        380        390        400        410        420 
VIHSLENPHS EEGGLRILKG NLAKDGAVIK SGATEVKRFE GPCVIFNSQD EALAGIMLGK 

       430        440        450        460        470        480 
VKKGDVVVIR YEGPRGGPGM PEMLAPTSAI AGMGLGADVA LLTDGRFSGA SRGISVGHIS 

       490        500        510        520        530        540 
PEAAAGGTIA LLEQGDIVCI DVEERLLEVR VSDEELDKRK KEWKRPEPKV KTGWLGRYAQ 

       550 
MVTSANTGAV LKIPNFD 

« Hide

References

[1]"Genome sequence of Bacillus cereus 03BB102."
Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 03BB102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001407 Genomic DNA. Translation: ACO26410.1.
RefSeqYP_002749134.1. NC_012472.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING572264.BCA_1859.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO26410; ACO26410; BCA_1859.
GeneID7689742.
KEGGbcx:BCA_1859.
PATRIC18816839. VBIBacCer84800_1736.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0129.
HOGENOMHOG000173155.
KOK01687.
OMAIPGHVHL.
OrthoDBEOG6MSS24.
ProtClustDBPRK00911.

Enzyme and pathway databases

BioCycBCER572264:GH22-1817-MONOMER.
UniPathwayUPA00047; UER00057.
UPA00049; UER00061.

Family and domain databases

HAMAPMF_00012. IlvD.
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERPTHR21000. PTHR21000. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. SSF52016. 1 hit.
TIGRFAMsTIGR00110. ilvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_BACC3
AccessionPrimary (citable) accession number: C1EPL6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways