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C1EPG6

- C1EPG6_BACC3

UniProt

C1EPG6 - C1EPG6_BACC3

Protein
Submitted name:

Malate oxidoreductase (Oxaloacetate-decarboxylating)

Gene

malS

Organism
Bacillus cereus (strain 03BB102)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Cofactori

    Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051Proton donorUniRule annotation
    Active sitei178 – 1781Proton acceptorUniRule annotation
    Metal bindingi249 – 2491Divalent metal cation
    Metal bindingi250 – 2501Divalent metal cation
    Metal bindingi273 – 2731Divalent metal cation

    GO - Molecular functioni

    1. malate dehydrogenase (decarboxylating) (NAD+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. NAD binding Source: InterPro
    4. oxaloacetate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. malate metabolic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciBCER572264:GH22-1767-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Malate oxidoreductase (Oxaloacetate-decarboxylating)Imported (EC:1.1.1.38Imported)
    Gene namesi
    Name:malSImported
    Ordered Locus Names:BCA_1808Imported
    OrganismiBacillus cereus (strain 03BB102)Imported
    Taxonomic identifieri572264 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002210: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi572264.BCA_1808.

    Structurei

    3D structure databases

    ProteinModelPortaliC1EPG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the malic enzymes family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0281.
    HOGENOMiHOG000042487.
    KOiK00027.
    OMAiDAQKPYA.
    OrthoDBiEOG6QVRGM.

    Family and domain databases

    Gene3Di3.40.50.10380. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR015884. Malic_enzyme_CS.
    IPR012301. Malic_N_dom.
    IPR012302. Malic_NAD-bd.
    IPR001891. Malic_OxRdtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00390. malic. 1 hit.
    PF03949. Malic_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000106. ME. 1 hit.
    PRINTSiPR00072. MALOXRDTASE.
    SMARTiSM00919. Malic_M. 1 hit.
    [Graphical view]
    PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1EPG6-1 [UniParc]FASTAAdd to Basket

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    MSKFTVASNG SLETTLRGVE VLSTPLLNKG VAFTQEEREE LGLKGLLPPA    50
    VLTLEEQARR AYEQFCSQPD DLLKNVYLTA LHDRNEVLFY RILTDHLREM 100
    LPIVYTPTVG VAIQRYSHEY RKPRGVYLSI NDPSGIEEAF ANIGATAENI 150
    DLVVVTDGEG ILGIGDWGVG GINIAIGKLA VYTAAVGIDP SRVLPVILDV 200
    GTNREELLNN PFYIGNRHPR ITGEAYDEFI DTFVQAVNKQ FPKALLHWED 250
    FSSRNARKIL DKYRHDICTF NDDIQGTGAV SLAAVLSAVK ASGVPLSEHR 300
    VVVFGAGTAG IGIADQVRDA MVRVGVSEEE SYKRFWCIDR NGLVTDNMED 350
    LLDFQMPYAR KEAEVSEWKE NGVIGLAEVV KHVKPTILIG TSTVAGAFKE 400
    EIIKEMASHV ERPIILPMSN PTPLAEAKPA DLIEWTEGRA LVATGSPFEP 450
    VTYNGVTYVI GQSNNALIFP GLGLGTIVVR ASVMTDGMFA AAAEAVASMV 500
    DTSQPGAPIL PEVEELRNIS EMVAIEVAKI AVAEGVAREN LSDNDIKIAV 550
    KEAIWEPEYR QIKAVEKVTI 570
    Length:570
    Mass (Da):62,244
    Last modified:May 26, 2009 - v1
    Checksum:i8F19CF19FC777689
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001407 Genomic DNA. Translation: ACO29382.1.
    RefSeqiYP_002749084.1. NC_012472.1.

    Genome annotation databases

    EnsemblBacteriaiACO29382; ACO29382; BCA_1808.
    GeneIDi7692437.
    KEGGibcx:BCA_1808.
    PATRICi18816735. VBIBacCer84800_1684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001407 Genomic DNA. Translation: ACO29382.1 .
    RefSeqi YP_002749084.1. NC_012472.1.

    3D structure databases

    ProteinModelPortali C1EPG6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572264.BCA_1808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO29382 ; ACO29382 ; BCA_1808 .
    GeneIDi 7692437.
    KEGGi bcx:BCA_1808.
    PATRICi 18816735. VBIBacCer84800_1684.

    Phylogenomic databases

    eggNOGi COG0281.
    HOGENOMi HOG000042487.
    KOi K00027.
    OMAi DAQKPYA.
    OrthoDBi EOG6QVRGM.

    Enzyme and pathway databases

    BioCyci BCER572264:GH22-1767-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10380. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR015884. Malic_enzyme_CS.
    IPR012301. Malic_N_dom.
    IPR012302. Malic_NAD-bd.
    IPR001891. Malic_OxRdtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00390. malic. 1 hit.
    PF03949. Malic_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000106. ME. 1 hit.
    PRINTSi PR00072. MALOXRDTASE.
    SMARTi SM00919. Malic_M. 1 hit.
    [Graphical view ]
    PROSITEi PS00331. MALIC_ENZYMES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus 03BB102."
      Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 03BB102Imported.

    Entry informationi

    Entry nameiC1EPG6_BACC3
    AccessioniPrimary (citable) accession number: C1EPG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3