C1DW75 (BIOW_SULAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-carboxyhexanoate--CoA ligase
EC=6.2.1.14

Alternative name(s):
Pimeloyl-CoA synthase

Gene names

Name:	bioW
Ordered Locus Names:	SULAZ_1395

Organism

Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825) [Complete proteome] [HAMAP]

Taxonomic identifier

204536 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Aquificae › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium › Sulfurihydrogenibium azorense

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP By similarity. HAMAP-Rule MF_00668
Catalytic activity	ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA. HAMAP-Rule MF_00668
Cofactor	Magnesium By similarity.
Pathway	Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis; pimeloyl-CoA from pimelate: step 1/1. HAMAP-Rule MF_00668
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the BioW family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	6-carboxyhexanoate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	6-carboxyhexanoate--CoA ligase HAMAP-Rule MF_00668		PRO_0000412089

Sequences

	Sequence		Length	Mass (Da)
	C1DW75 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 6A4A75479A9D78EF	FASTA	245	27,940
	10 20 30 40 50 60 MKEYFSVKMR ASLQGRHVSG AERIVLKEDL PTVISQLSQR PKEYDSLNIK VEKINDLNYI 70 80 90 100 110 120 EKSLNVKTIN VKDWIEGNKV AVEILQNQGV DKKIAEKYIN LIHQGAVNGE NMRGAMIVNL 130 140 150 160 170 180 SGERVEKDKT RGIRTVNIDF EDRKAITELL KEKGYTERTV DALALATKTL NHPDIVAEYC 190 200 210 220 230 240 ISDDPSYTTG YVATKTTYYR INPLKQLSNE KGGRIYFVKD TANIEDIYQY LESEAFLIKQ LGDLQ

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Az-Fu1 / DSM 15241 / OCM 825.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001229 Genomic DNA. Translation: ACN98309.1.
RefSeq	YP_002729362.1. NC_012438.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	204536.SULAZ_1395.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACN98309; ACN98309; SULAZ_1395.
GeneID	7673314.
KEGG	saf:SULAZ_1395.
PATRIC	23763910. VBISulAzo123226_1354.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1424.
HOGENOM	HOG000253976.
KO	K01906.
OMA	TTGYVAT.
ProtClustDB	PRK01322.
Enzyme and pathway databases
BioCyc	SAZO204536:GHRE-210-MONOMER.
UniPathway	UPA00999; UER00351.
Family and domain databases
HAMAP	MF_00668. BioW.
InterPro	IPR005499. BioW. [Graphical view]
Pfam	PF03744. BioW. 1 hit. [Graphical view]
ProDom	PD017229. BioW. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01204. bioW. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOW_SULAA

Accession

Primary (citable) accession number: C1DW75

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program