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C1DVP8 (C1DVP8_SULAA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine--tRNA ligase HAMAP-Rule MF_00176
EC=6.1.1.11 HAMAP-Rule MF_00176
Alternative name(s):
Seryl-tRNA synthetase HAMAP-Rule MF_00176
Seryl-tRNA(Ser/Sec) synthetase HAMAP-Rule MF_00176
Gene names
Name:serS HAMAP-Rule MF_00176
Ordered Locus Names:SULAZ_1214
OrganismSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825) [Complete proteome] [HAMAP] EMBL ACN98261.1
Taxonomic identifier204536 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium ›

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity. HAMAP-Rule MF_00176

Catalytic activity

ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec). HAMAP-Rule MF_00176

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). HAMAP-Rule MF_00176

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. HAMAP-Rule MF_00176

Subunit structure

Homodimer. The tRNA molecule binds across the dimer By similarity. HAMAP-Rule MF_00176

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00176.

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity. HAMAP-Rule MF_00176

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. HAMAP-Rule MF_00176

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding263 – 2653ATP By similarity HAMAP-Rule MF_00176
Nucleotide binding350 – 3534ATP By similarity HAMAP-Rule MF_00176
Region232 – 2343Serine binding By similarity HAMAP-Rule MF_00176

Sites

Binding site2861Serine By similarity HAMAP-Rule MF_00176
Binding site3851Serine By similarity HAMAP-Rule MF_00176

Sequences

Sequence LengthMass (Da)Tools
C1DVP8 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: BE2977C2600EF2EA

FASTA41748,748
        10         20         30         40         50         60 
MLDIRLIREK PDFVKERLST RDPSYAQMID KLLEIDEERR KIKKEIDDLR AERNEKSKLF 

        70         80         90        100        110        120 
PIYKKEGKDT TQIQERVKEI GERIKYLEEK LNTVEEEFNN LILYIPNLPA LDVPIGKDEN 

       130        140        150        160        170        180 
DNVEVRRWGE SRKFDFEPLP HFEIGERLGI LDFERGAKLS GSRFTVMFKE AARLERALIN 

       190        200        210        220        230        240 
FMLDVHTKQH GYTEVWTPLL VKSKTLQGTG QLPKFKEDLY KIEDEDLYLI PTAEVTLTNL 

       250        260        270        280        290        300 
HADEIIPEDQ LPKYYTAYTP CFRKEAGSHG KDVRGILRQH QFDKVELVKI VKPEDSYNEL 

       310        320        330        340        350        360 
EKLVNEAEKI LQLLELPYRV VLLCTGDMGF SAAKTYDIEV WIPSQNRYRE ISSCSNTEDF 

       370        380        390        400        410 
QARRAMIRYK DKEGKNHFVH TLNGSGLAVG RTLLAIIENY QKPDGTFEVP KVLRDYL

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References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Az-Fu1 / DSM 15241 / OCM 825.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001229 Genomic DNA. Translation: ACN98261.1.
RefSeqYP_002729185.1. NC_012438.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING204536.SULAZ_1214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN98261; ACN98261; SULAZ_1214.
GeneID7672730.
KEGGsaf:SULAZ_1214.
PATRIC23763554. VBISulAzo123226_1177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0172.
HOGENOMHOG000035937.
KOK01875.
OMAEESWEWH.
ProtClustDBPRK05431.

Enzyme and pathway databases

BioCycSAZO204536:GHRE-162-MONOMER.
UniPathwayUPA00906; UER00895.

Family and domain databases

Gene3D1.10.287.40. 1 hit.
HAMAPMF_00176. Ser_tRNA_synth_type1.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view]
PANTHERPTHR11778. PTHR11778. 1 hit.
PfamPF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSPR00981. TRNASYNTHSER.
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
TIGRFAMsTIGR00414. serS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC1DVP8_SULAA
AccessionPrimary (citable) accession number: C1DVP8
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info