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C1DUY4

- GSA_SULAA

UniProt

C1DUY4 - GSA_SULAA

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, SULAZ_0948
Organism
Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSAZO204536:GHRE-947-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:SULAZ_0948
OrganismiSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Taxonomic identifieri204536 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001369: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_0000382384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi204536.SULAZ_0948.

Structurei

3D structure databases

ProteinModelPortaliC1DUY4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DUY4-1 [UniParc]FASTAAdd to Basket

« Hide

MNILKSKELF KEAQNYLVGG VNSPVRAFKA VGTDPIFIQR GKGSRIWDVD    50
GNEYIDYVLS WGPLILGHAH DQVVNAIKQV ANYGTSFGAP TELEIEMAKA 100
VVDAVKSVEM VRFVNSGTEA TMSAIRLARG YTKRKKIVKF DGCYHGHGDS 150
LLVSAGSGVA TLGIPGTPGI PEELANLTIV LPYNDIEAVE EAFKRYGEDI 200
ACVIIEPVAG NMGVVAPSKE YHQRLRDITR KYGALLIFDE VMTGFRLAYG 250
GAQELYGIDP DLTTFGKVIG GGLPVGAYGG KREIMEYVAP VGPVYQAGTL 300
SGNPLAMAAG LRQLQLLKEL NPYRELDEKG RFLEEGFKQI AQEFSAAIQV 350
NRVGSMITVF FTDIPVKDFA TAKTSDTNKF AKFFRCMLEK GIYLPASQFE 400
AFFLSTAHSQ KDLEETLEKA RECFKIL 427
Length:427
Mass (Da):46,798
Last modified:May 26, 2009 - v1
Checksum:i7A80879D7DD1AD31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN98435.1.
RefSeqiYP_002728921.1. NC_012438.1.

Genome annotation databases

EnsemblBacteriaiACN98435; ACN98435; SULAZ_0948.
GeneIDi7672681.
KEGGisaf:SULAZ_0948.
PATRICi23763024. VBISulAzo123226_0915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN98435.1 .
RefSeqi YP_002728921.1. NC_012438.1.

3D structure databases

ProteinModelPortali C1DUY4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204536.SULAZ_0948.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN98435 ; ACN98435 ; SULAZ_0948 .
GeneIDi 7672681.
KEGGi saf:SULAZ_0948.
PATRICi 23763024. VBISulAzo123226_0915.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci SAZO204536:GHRE-947-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Az-Fu1 / DSM 15241 / OCM 825.

Entry informationi

Entry nameiGSA_SULAA
AccessioniPrimary (citable) accession number: C1DUY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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