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C1DU20

- C1DU20_SULAA

UniProt

C1DU20 - C1DU20_SULAA

Protein

NAD kinase

Gene

nadK

Organism
Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641Proton acceptorUniRule annotation
    Binding sitei149 – 1491NADUniRule annotation
    Binding sitei168 – 1681NADUniRule annotation
    Binding sitei238 – 2381NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 652NADUniRule annotation
    Nucleotide bindingi138 – 1392NADUniRule annotation
    Nucleotide bindingi179 – 1846NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAZO204536:GHRE-620-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:SULAZ_0622Imported
    OrganismiSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)Imported
    Taxonomic identifieri204536 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
    ProteomesiUP000001369: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi204536.SULAZ_0622.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiHPSIPGW.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1DU20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAILPIYKKL RIFSKQSEEA KNFSKNLNDW LIKKGIESKI IENVQDLEKG    50
    EIKEIDALIV VGGDGSLLIA SRRVAKYGIP LIGINLGRLG FLTEINKEEA 100
    YEKLEDILSK PLCISKRMML RATLKRDGKE VLTADVLNDV IVNKAILARI 150
    VDVAVYVGDR YITTFNGDGV IVSTPTGSTA YALSAGGPIV YPPLEVFVLV 200
    PICPHTLTDR PIILPTTEPI KIKLISKDKD AWLTLDGQEG TQLFYGDEIV 250
    VKQSPYYTFI VRTPYKNYFD ILREKLNWK 279
    Length:279
    Mass (Da):31,303
    Last modified:May 26, 2009 - v1
    Checksum:i1AF66937DD55C82B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001229 Genomic DNA. Translation: ACN99465.1.
    RefSeqiYP_002728607.1. NC_012438.1.

    Genome annotation databases

    EnsemblBacteriaiACN99465; ACN99465; SULAZ_0622.
    GeneIDi7674172.
    KEGGisaf:SULAZ_0622.
    PATRICi23762374. VBISulAzo123226_0603.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001229 Genomic DNA. Translation: ACN99465.1 .
    RefSeqi YP_002728607.1. NC_012438.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204536.SULAZ_0622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN99465 ; ACN99465 ; SULAZ_0622 .
    GeneIDi 7674172.
    KEGGi saf:SULAZ_0622.
    PATRICi 23762374. VBISulAzo123226_0603.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi HPSIPGW.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci SAZO204536:GHRE-620-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Az-Fu1 / DSM 15241 / OCM 825Imported.

    Entry informationi

    Entry nameiC1DU20_SULAA
    AccessioniPrimary (citable) accession number: C1DU20
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3