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C1DU20 (C1DU20_SULAA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase HAMAP-Rule MF_00361

EC=2.7.1.23 HAMAP-Rule MF_00361
Alternative name(s):
ATP-dependent NAD kinase HAMAP-Rule MF_00361
Gene names
Name:nadK HAMAP-Rule MF_00361
Ordered Locus Names:SULAZ_0622 EMBL ACN99465.1
OrganismSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825) [Complete proteome] [HAMAP] EMBL ACN99465.1
Taxonomic identifier204536 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361 SAAS SAAS002504

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361 SAAS SAAS002504.

Sequence similarities

Belongs to the NAD kinase family. HAMAP-Rule MF_00361

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding64 – 652NAD By similarity HAMAP-Rule MF_00361
Nucleotide binding138 – 1392NAD By similarity HAMAP-Rule MF_00361
Nucleotide binding179 – 1846NAD By similarity HAMAP-Rule MF_00361

Sites

Active site641Proton acceptor By similarity HAMAP-Rule MF_00361
Binding site1491NAD By similarity HAMAP-Rule MF_00361
Binding site1681NAD By similarity HAMAP-Rule MF_00361
Binding site2381NAD By similarity HAMAP-Rule MF_00361

Sequences

Sequence LengthMass (Da)Tools
C1DU20 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 1AF66937DD55C82B

FASTA27931,303
        10         20         30         40         50         60 
MAILPIYKKL RIFSKQSEEA KNFSKNLNDW LIKKGIESKI IENVQDLEKG EIKEIDALIV 

        70         80         90        100        110        120 
VGGDGSLLIA SRRVAKYGIP LIGINLGRLG FLTEINKEEA YEKLEDILSK PLCISKRMML 

       130        140        150        160        170        180 
RATLKRDGKE VLTADVLNDV IVNKAILARI VDVAVYVGDR YITTFNGDGV IVSTPTGSTA 

       190        200        210        220        230        240 
YALSAGGPIV YPPLEVFVLV PICPHTLTDR PIILPTTEPI KIKLISKDKD AWLTLDGQEG 

       250        260        270 
TQLFYGDEIV VKQSPYYTFI VRTPYKNYFD ILREKLNWK 

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Az-Fu1 / DSM 15241 / OCM 825.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001229 Genomic DNA. Translation: ACN99465.1.
RefSeqYP_002728607.1. NC_012438.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204536.SULAZ_0622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN99465; ACN99465; SULAZ_0622.
GeneID7674172.
KEGGsaf:SULAZ_0622.
PATRIC23762374. VBISulAzo123226_0603.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMAHPSIPGW.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycSAZO204536:GHRE-620-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1DU20_SULAA
AccessionPrimary (citable) accession number: C1DU20
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)