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C1DU20

- C1DU20_SULAA

UniProt

C1DU20 - C1DU20_SULAA

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Protein

NAD kinase

Gene

nadK

Organism
Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Proton acceptorUniRule annotation
Binding sitei149 – 1491NADUniRule annotation
Binding sitei168 – 1681NADUniRule annotation
Binding sitei238 – 2381NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 652NADUniRule annotation
Nucleotide bindingi138 – 1392NADUniRule annotation
Nucleotide bindingi179 – 1846NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAZO204536:GHRE-620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SULAZ_0622Imported
OrganismiSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)Imported
Taxonomic identifieri204536 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001369: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi204536.SULAZ_0622.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DU20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAILPIYKKL RIFSKQSEEA KNFSKNLNDW LIKKGIESKI IENVQDLEKG
60 70 80 90 100
EIKEIDALIV VGGDGSLLIA SRRVAKYGIP LIGINLGRLG FLTEINKEEA
110 120 130 140 150
YEKLEDILSK PLCISKRMML RATLKRDGKE VLTADVLNDV IVNKAILARI
160 170 180 190 200
VDVAVYVGDR YITTFNGDGV IVSTPTGSTA YALSAGGPIV YPPLEVFVLV
210 220 230 240 250
PICPHTLTDR PIILPTTEPI KIKLISKDKD AWLTLDGQEG TQLFYGDEIV
260 270
VKQSPYYTFI VRTPYKNYFD ILREKLNWK
Length:279
Mass (Da):31,303
Last modified:May 26, 2009 - v1
Checksum:i1AF66937DD55C82B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN99465.1.
RefSeqiYP_002728607.1. NC_012438.1.

Genome annotation databases

EnsemblBacteriaiACN99465; ACN99465; SULAZ_0622.
GeneIDi7674172.
KEGGisaf:SULAZ_0622.
PATRICi23762374. VBISulAzo123226_0603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN99465.1 .
RefSeqi YP_002728607.1. NC_012438.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204536.SULAZ_0622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN99465 ; ACN99465 ; SULAZ_0622 .
GeneIDi 7674172.
KEGGi saf:SULAZ_0622.
PATRICi 23762374. VBISulAzo123226_0603.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SAZO204536:GHRE-620-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Az-Fu1 / DSM 15241 / OCM 825Imported.

Entry informationi

Entry nameiC1DU20_SULAA
AccessioniPrimary (citable) accession number: C1DU20
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3