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C1DTW6

- PNP_SULAA

UniProt

C1DTW6 - PNP_SULAA

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, SULAZ_0563
Organism
Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi486 – 4861Magnesium By similarity
Metal bindingi492 – 4921Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSAZO204536:GHRE-561-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:SULAZ_0563
OrganismiSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Taxonomic identifieri204536 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001369: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000381922Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204536.SULAZ_0563.

Structurei

3D structure databases

ProteinModelPortaliC1DTW6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KH
Add
BLAST
Domaini622 – 69069S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DTW6-1 [UniParc]FASTAAdd to Basket

« Hide

MEIEEIKVQT EVNGAPFIIE TGYFAKQANG AVIVRQGDTA VLVAAVMSEE    50
PQADIDFLPL TVEYREKYYA YGKIPGGFVK REGKPTDREI LVARNIDRPI 100
RPLFPKGFYN DIVITAYTLS ADDKYDPDVL GIVGASAALH ISDIPFEGPI 150
AGVRVCRVNG EFIVNPTYQQ KAQADIEIVV AGSKDAIVMV EGGAKEVPEE 200
DILEAMMFGH QEIKKLIELQ EELRLKCGKE KIQVAIDEEE IILKDKLKEF 250
SYEKIKEAFK ITDKKQRNKT INAIFEEAFK TLEIPEEKIK KASFIYKDIV 300
SNVMRDNILN EGIRIDGRKP EEIRPIWIKV GVFPRNHGSA IFTRGQTQAF 350
VTVTLGSLSE GQIEESIEAG EVMKRFMLHY NFPPFSTGEA KPPRATSRRE 400
IGHGNLAERA LEPLIPPEEE FPYAIRVVSD ILESNGSTSM ATVCGGSLAL 450
FDAGVPMKKH VAGIAMGLIK AEDKFVILSD ILGDEDHLGD MDFKVAGTRD 500
GVTSIQMDIK VKGLTKEILE KALQQARDGR NYILDLMYQA IPEPRKEVSP 550
YAPTVTTLRV LPDKIPIIIG PAGKNIKKII EETKVKIDLD PEGLVKIYAT 600
SKEAAEKAVS MINELILDVE VGEVYMGKVT RVEDYGAFVE LLPGRLSLLH 650
VSQITGERLK SAKEKIKVGD VLKVKVSEID DQGRIKVSLK DVPENVEPKN 700
KFLFKEE 707
Length:707
Mass (Da):78,670
Last modified:May 26, 2009 - v1
Checksum:iEBAD8CC9DC73A88D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN99597.1.
RefSeqiYP_002728553.1. NC_012438.1.

Genome annotation databases

EnsemblBacteriaiACN99597; ACN99597; SULAZ_0563.
GeneIDi7673924.
KEGGisaf:SULAZ_0563.
PATRICi23762256. VBISulAzo123226_0549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN99597.1 .
RefSeqi YP_002728553.1. NC_012438.1.

3D structure databases

ProteinModelPortali C1DTW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204536.SULAZ_0563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN99597 ; ACN99597 ; SULAZ_0563 .
GeneIDi 7673924.
KEGGi saf:SULAZ_0563.
PATRICi 23762256. VBISulAzo123226_0549.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SAZO204536:GHRE-561-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Az-Fu1 / DSM 15241 / OCM 825.

Entry informationi

Entry nameiPNP_SULAA
AccessioniPrimary (citable) accession number: C1DTW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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