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C1DTW6

- PNP_SULAA

UniProt

C1DTW6 - PNP_SULAA

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi486 – 4861MagnesiumUniRule annotation
Metal bindingi492 – 4921MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSAZO204536:GHRE-561-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:SULAZ_0563
OrganismiSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)
Taxonomic identifieri204536 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001369: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Polyribonucleotide nucleotidyltransferasePRO_0000381922Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204536.SULAZ_0563.

Structurei

3D structure databases

ProteinModelPortaliC1DTW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KHUniRule annotationAdd
BLAST
Domaini622 – 69069S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DTW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIEEIKVQT EVNGAPFIIE TGYFAKQANG AVIVRQGDTA VLVAAVMSEE
60 70 80 90 100
PQADIDFLPL TVEYREKYYA YGKIPGGFVK REGKPTDREI LVARNIDRPI
110 120 130 140 150
RPLFPKGFYN DIVITAYTLS ADDKYDPDVL GIVGASAALH ISDIPFEGPI
160 170 180 190 200
AGVRVCRVNG EFIVNPTYQQ KAQADIEIVV AGSKDAIVMV EGGAKEVPEE
210 220 230 240 250
DILEAMMFGH QEIKKLIELQ EELRLKCGKE KIQVAIDEEE IILKDKLKEF
260 270 280 290 300
SYEKIKEAFK ITDKKQRNKT INAIFEEAFK TLEIPEEKIK KASFIYKDIV
310 320 330 340 350
SNVMRDNILN EGIRIDGRKP EEIRPIWIKV GVFPRNHGSA IFTRGQTQAF
360 370 380 390 400
VTVTLGSLSE GQIEESIEAG EVMKRFMLHY NFPPFSTGEA KPPRATSRRE
410 420 430 440 450
IGHGNLAERA LEPLIPPEEE FPYAIRVVSD ILESNGSTSM ATVCGGSLAL
460 470 480 490 500
FDAGVPMKKH VAGIAMGLIK AEDKFVILSD ILGDEDHLGD MDFKVAGTRD
510 520 530 540 550
GVTSIQMDIK VKGLTKEILE KALQQARDGR NYILDLMYQA IPEPRKEVSP
560 570 580 590 600
YAPTVTTLRV LPDKIPIIIG PAGKNIKKII EETKVKIDLD PEGLVKIYAT
610 620 630 640 650
SKEAAEKAVS MINELILDVE VGEVYMGKVT RVEDYGAFVE LLPGRLSLLH
660 670 680 690 700
VSQITGERLK SAKEKIKVGD VLKVKVSEID DQGRIKVSLK DVPENVEPKN

KFLFKEE
Length:707
Mass (Da):78,670
Last modified:May 26, 2009 - v1
Checksum:iEBAD8CC9DC73A88D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN99597.1.
RefSeqiYP_002728553.1. NC_012438.1.

Genome annotation databases

EnsemblBacteriaiACN99597; ACN99597; SULAZ_0563.
GeneIDi7673924.
KEGGisaf:SULAZ_0563.
PATRICi23762256. VBISulAzo123226_0549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001229 Genomic DNA. Translation: ACN99597.1 .
RefSeqi YP_002728553.1. NC_012438.1.

3D structure databases

ProteinModelPortali C1DTW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204536.SULAZ_0563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN99597 ; ACN99597 ; SULAZ_0563 .
GeneIDi 7673924.
KEGGi saf:SULAZ_0563.
PATRICi 23762256. VBISulAzo123226_0549.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SAZO204536:GHRE-561-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Az-Fu1 / DSM 15241 / OCM 825.

Entry informationi

Entry nameiPNP_SULAA
AccessioniPrimary (citable) accession number: C1DTW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3