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C1DTI2 (C1DTI2_SULAA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein FolD HAMAP-Rule MF_01576
Gene names
Name:folD HAMAP-Rule MF_01576
Ordered Locus Names:SULAZ_0428
OrganismSulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825) [Complete proteome] [HAMAP] EMBL ACN98777.1
Taxonomic identifier204536 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium ›

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP-Rule MF_01576 SAAS SAAS020867

Catalytic activity

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP-Rule MF_01576 SAAS SAAS020867

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP-Rule MF_01576 SAAS SAAS020867

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01576 SAAS SAAS020867

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01576 SAAS SAAS020867

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. HAMAP-Rule MF_01576

Sequences

Sequence LengthMass (Da)Tools
C1DTI2 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: A06E6021829C3CF4

FASTA28431,015
        10         20         30         40         50         60 
MILLNGKELA EKIKNQIKQE LQEFLNKGYR RPTLAVILVG ENPASQIYVN KKIKDCQSVG 

        70         80         90        100        110        120 
INSKPFFLPE NITQIELLDL IGQLNGDEEV DGILVQLPLP SHINTLEIIE AINPKKDVDG 

       130        140        150        160        170        180 
FHPLNVGKLA TGRNDGIIPC TPYGIMKLLE YYNIDTFGKD VVVVGASNIV GKPMSLLFLK 

       190        200        210        220        230        240 
DEKSTVTICH KNTKDLKSHT LKADILVVAV GKPKLITADM VKEGAVVIDV GINRVDGKIV 

       250        260        270        280 
GDVDFENVSK KVSAITPVPG GVGPMTVAML LYNTFQAYKN NVIS

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References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Az-Fu1 / DSM 15241 / OCM 825.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001229 Genomic DNA. Translation: ACN98777.1.
RefSeqYP_002728419.1. NC_012438.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING204536.SULAZ_0428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN98777; ACN98777; SULAZ_0428.
GeneID7673647.
KEGGsaf:SULAZ_0428.
PATRIC23761984. VBISulAzo123226_0415.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0190.
HOGENOMHOG000218242.
KOK01491.
OMAAASAVXH.
ProtClustDBCLSK2479639.

Enzyme and pathway databases

BioCycSAZO204536:GHRE-677-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01576. THF_DHG_CYH.
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC1DTI2_SULAA
AccessionPrimary (citable) accession number: C1DTI2
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info