C1DTG6 (C1DTG6_SULAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
EC=2.1.2.9 HAMAP-Rule MF_00182

Gene names

Name:	fmt HAMAP-Rule MF_00182
Ordered Locus Names:	SULAZ_0409

Organism

Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825) [Complete proteome] [HAMAP] EMBL ACN98936.1

Taxonomic identifier

204536 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Aquificae › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium › Sulfurihydrogenibium azorense

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182 SAAS SAAS005794
Catalytic activity	10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182 SAAS SAAS005794
Sequence similarities	Belongs to the fmt family. HAMAP-Rule MF_00182

Ontologies

Keywords
Biological process	Protein biosynthesis HAMAP-Rule MF_00182 SAAS SAAS005794
Molecular function	Methyltransferase HAMAP-Rule MF_00182 SAAS SAAS005794 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translational initiation Inferred from electronic annotation. Source: GOC
Molecular_function	methionyl-tRNA formyltransferase activity Inferred from electronic annotation. Source: HAMAP methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	110 – 113	4	Tetrahydrofolate (THF) binding By similarity HAMAP-Rule MF_00182

Sequences

	Sequence		Length	Mass (Da)
	C1DTG6 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: DCF2391F4AB43C8C	FASTA	311	34,996
	10 20 30 40 50 60 MKVLFWGTPE FAVESLKALI QSNHQVVAVI TQPDKPKGRG QKVQPPPVKE EALKHNIPVL 70 80 90 100 110 120 QPEKIKNNQE FVETIKQLNP DISVVVAYGK ILPEEIINIP KYKTINVHAS LLPKYRGAAP 130 140 150 160 170 180 IQRAIMDGEE ETGVCIMEIV KELDAGDVYA CTKVKILPED DIITLHDKLA KEGAKLLIEV 190 200 210 220 230 240 LDKIEKGQIE KVPQDHSKAT YAKPIEKEEG KIDWNKPAKD IFNQVRALKV WPKAFANFRD 250 260 270 280 290 300 FQVKILNVEV LKECKEGKPG EILKASDKEG IVVKTKDGCL LIRTIQFPNS KPISSQEAVR 310 GYRIKEGEKF E

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Az-Fu1 / DSM 15241 / OCM 825.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001229 Genomic DNA. Translation: ACN98936.1.
RefSeq	YP_002728403.1. NC_012438.1.
3D structure databases
ProteinModelPortal	C1DTG6.
ModBase	Search...
Protein-protein interaction databases
STRING	204536.SULAZ_0409.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACN98936; ACN98936; SULAZ_0409.
GeneID	7673096.
KEGG	saf:SULAZ_0409.
PATRIC	23761948. VBISulAzo123226_0399.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0223.
HOGENOM	HOG000261177.
KO	K00604.
OMA	GITLMQM.
ProtClustDB	CLSK2479570.
Enzyme and pathway databases
BioCyc	SAZO204536:GHRE-836-MONOMER.
Family and domain databases
Gene3D	3.10.25.10. 1 hit. 3.40.50.170. 1 hit.
HAMAP	MF_00182. Formyl_trans.
InterPro	IPR005794. Fmt. IPR005793. Formyl_trans_C. IPR002376. Formyl_transf_N. IPR011034. Formyl_transferase_C-like. IPR015518. Met_tRNA_Form_TA-like. [Graphical view]
PANTHER	PTHR11138. PTHR11138. 1 hit.
Pfam	PF02911. Formyl_trans_C. 1 hit. PF00551. Formyl_trans_N. 1 hit. [Graphical view]
SUPFAM	SSF50486. FMT_C_like. 1 hit. SSF53328. formyl_transf. 1 hit.
TIGRFAMs	TIGR00460. fmt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C1DTG6_SULAA

Accession

Primary (citable) accession number: C1DTG6

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)