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C1DST3

- LPXB_AZOVD

UniProt

C1DST3 - LPXB_AZOVD

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, Avin_38860
Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-3891-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Avin_38860
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Lipid-A-disaccharide synthaseUniRule annotationPRO_1000205843Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_38860.

Structurei

3D structure databases

ProteinModelPortaliC1DST3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DST3-1 [UniParc]FASTAAdd to Basket

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MAGVLRVALV AGEASGDILG ASLMQALKAV RPDIEFIGVG GPRMQAEGLQ    50
SYFPMERLAV MGLFEVLGRL PELLLRRRWL IRDLLEARPD LYIGIDAPDF 100
NLGIELRLRR AGIRTVHYVS PSVWAWRQKR VLKIRQACDL MLTLFPFEAE 150
FYEARNVPVR FVGHPLADQI PLQTDRDAAR AALDLTDGET IVALLPGSRG 200
GELARLGPLF IEAAERLLAL HAGPLRFVVP CASPERRRQL EEMLSHTRRD 250
LPVMLLDGRS HEALAACDAV LIASGTATLE ALLYKRPMVV AYRLAPLTYK 300
VARHLVKTPF FSLPNLLAGR ALVPELLQDR ATPEALAEAL IPLLEIGGEQ 350
TECFDAIHRS LRRDASRRAA ESVLELAERA 380
Length:380
Mass (Da):42,115
Last modified:May 26, 2009 - v1
Checksum:i43802C385EDC4C88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO80026.1.
RefSeqiYP_002801001.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO80026; ACO80026; Avin_38860.
GeneIDi7762775.
KEGGiavn:Avin_38860.
PATRICi21033818. VBIAzoVin72790_3651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO80026.1 .
RefSeqi YP_002801001.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DST3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_38860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO80026 ; ACO80026 ; Avin_38860 .
GeneIDi 7762775.
KEGGi avn:Avin_38860.
PATRICi 21033818. VBIAzoVin72790_3651.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci AVIN322710:GJ0M-3891-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiLPXB_AZOVD
AccessioniPrimary (citable) accession number: C1DST3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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