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C1DST3 (LPXB_AZOVD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:Avin_38860
OrganismAzotobacter vinelandii (strain DJ / ATCC BAA-1303) [Complete proteome] [HAMAP]
Taxonomic identifier322710 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000205843

Sequences

Sequence LengthMass (Da)Tools
C1DST3 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 43802C385EDC4C88

FASTA38042,115
        10         20         30         40         50         60 
MAGVLRVALV AGEASGDILG ASLMQALKAV RPDIEFIGVG GPRMQAEGLQ SYFPMERLAV 

        70         80         90        100        110        120 
MGLFEVLGRL PELLLRRRWL IRDLLEARPD LYIGIDAPDF NLGIELRLRR AGIRTVHYVS 

       130        140        150        160        170        180 
PSVWAWRQKR VLKIRQACDL MLTLFPFEAE FYEARNVPVR FVGHPLADQI PLQTDRDAAR 

       190        200        210        220        230        240 
AALDLTDGET IVALLPGSRG GELARLGPLF IEAAERLLAL HAGPLRFVVP CASPERRRQL 

       250        260        270        280        290        300 
EEMLSHTRRD LPVMLLDGRS HEALAACDAV LIASGTATLE ALLYKRPMVV AYRLAPLTYK 

       310        320        330        340        350        360 
VARHLVKTPF FSLPNLLAGR ALVPELLQDR ATPEALAEAL IPLLEIGGEQ TECFDAIHRS 

       370        380 
LRRDASRRAA ESVLELAERA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001157 Genomic DNA. Translation: ACO80026.1.
RefSeqYP_002801001.1. NC_012560.1.

3D structure databases

ProteinModelPortalC1DST3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING322710.Avin_38860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO80026; ACO80026; Avin_38860.
GeneID7762775.
KEGGavn:Avin_38860.
PATRIC21033818. VBIAzoVin72790_3651.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBPRK00025.

Enzyme and pathway databases

BioCycAVIN322710:GJ0M-3891-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_AZOVD
AccessionPrimary (citable) accession number: C1DST3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways