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Protein

Thiopurine S-methyltransferase

Gene

tpm

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101S-adenosyl-L-methionineUniRule annotation
Binding sitei45 – 451S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei66 – 661S-adenosyl-L-methionineUniRule annotation
Binding sitei123 – 1231S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-1539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation)
Alternative name(s):
Thiopurine methyltransferaseUniRule annotation
Gene namesi
Name:tpmUniRule annotation
Ordered Locus Names:Avin_15380
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
Proteomesi
  • UP000002424 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Thiopurine S-methyltransferasePRO_1000213022Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_15380.

Structurei

3D structure databases

ProteinModelPortaliC1DRL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FQ6. Bacteria.
ENOG4111GNF. LUCA.
HOGENOMiHOG000276919.
KOiK00569.
OMAiPTWVETH.
OrthoDBiEOG6K3ZZV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00812. Thiopur_methtran.
InterProiIPR029063. SAM-dependent_MTases.
IPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR025835. Thiopurine_S-MeTrfase.
IPR008854. TPMT.
[Graphical view]
PfamiPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFiPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR03840. TMPT_Se_Te. 1 hit.
PROSITEiPS51585. SAM_MT_TPMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DRL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEDFWQARW ARDEIGFHQA QVNPYLSRHW PTLGLAPGSR VLVPLCGKSL
60 70 80 90 100
DLAWLAGQGF AVLGVELAEK AVRDFFDEQR LIPQVDSQGV FRVYRVGSLE
110 120 130 140 150
IRCGDFFALS AADVADCRGL YDRAALIALP TEMRERYAAH LSAILPSGCR
160 170 180 190 200
GLLVCLDYDQ TRMGGPPFAV DDHEVRRLLG TDWQVRLLEA PDVLRENWKF
210
LQRGLDRLEE RVYRLERR
Length:218
Mass (Da):24,925
Last modified:May 26, 2009 - v1
Checksum:i34D6AB0564E81F7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO77753.1.
RefSeqiWP_012700169.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO77753; ACO77753; Avin_15380.
KEGGiavn:Avin_15380.
PATRICi21029364. VBIAzoVin72790_1464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO77753.1.
RefSeqiWP_012700169.1. NC_012560.1.

3D structure databases

ProteinModelPortaliC1DRL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_15380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO77753; ACO77753; Avin_15380.
KEGGiavn:Avin_15380.
PATRICi21029364. VBIAzoVin72790_1464.

Phylogenomic databases

eggNOGiENOG4105FQ6. Bacteria.
ENOG4111GNF. LUCA.
HOGENOMiHOG000276919.
KOiK00569.
OMAiPTWVETH.
OrthoDBiEOG6K3ZZV.

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-1539-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00812. Thiopur_methtran.
InterProiIPR029063. SAM-dependent_MTases.
IPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR025835. Thiopurine_S-MeTrfase.
IPR008854. TPMT.
[Graphical view]
PfamiPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFiPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR03840. TMPT_Se_Te. 1 hit.
PROSITEiPS51585. SAM_MT_TPMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiTPMT_AZOVD
AccessioniPrimary (citable) accession number: C1DRL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: December 9, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.