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C1DRI9

- ACDH2_AZOVD

UniProt

C1DRI9 - ACDH2_AZOVD

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Protein

Acetaldehyde dehydrogenase 2

Gene
mhpF, Avin_15120
Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Acyl-thioester intermediate By similarity
Binding sitei289 – 2891NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NAD By similarity
Nucleotide bindingi162 – 1709NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-1513-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Name:mhpF
Ordered Locus Names:Avin_15120
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Acetaldehyde dehydrogenase 2UniRule annotationPRO_0000387620Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_15120.

Structurei

3D structure databases

ProteinModelPortaliC1DRI9.
SMRiC1DRI9. Positions 2-311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
OMAiYVIPSIN.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DRI9-1 [UniParc]FASTAAdd to Basket

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MKKLKVAIVG SGNIGTDLMI KILRHGQHLE MGALVGIDPD SDGLARAARL    50
GVATTAEGVE GLARLPGFGE IDFVFDATSA AAHVKNDPFL RGLRPGLRLI 100
DLTPAAVGPY CVPVVNLEQN LREPNVNMVT CGGQATIPMV AAVSRVARVH 150
YAEIVASIAS RSAGPGTRAN IDEFTETTSK AIEAIGGARK GKAIIVLNPA 200
EPPLIMRDTV YVLSAPADQA RVEASLAEMA QAVQGYVPGY RLKQRVQFDE 250
IPDAAPLNIP GLGRLSGLKT SVFLEVEGAA HYLPAYAGNL DIMTSAALAT 300
AERMAQSMLN A 311
Length:311
Mass (Da):32,656
Last modified:May 26, 2009 - v1
Checksum:iB14C3AAC1683824A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO77727.1.
RefSeqiYP_002798702.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO77727; ACO77727; Avin_15120.
GeneIDi7760447.
KEGGiavn:Avin_15120.
PATRICi21029311. VBIAzoVin72790_1438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO77727.1 .
RefSeqi YP_002798702.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DRI9.
SMRi C1DRI9. Positions 2-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_15120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO77727 ; ACO77727 ; Avin_15120 .
GeneIDi 7760447.
KEGGi avn:Avin_15120.
PATRICi 21029311. VBIAzoVin72790_1438.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
OMAi YVIPSIN.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci AVIN322710:GJ0M-1513-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiACDH2_AZOVD
AccessioniPrimary (citable) accession number: C1DRI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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