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C1DRI9 (ACDH2_AZOVD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Name:mhpF
Ordered Locus Names:Avin_15120
OrganismAzotobacter vinelandii (strain DJ / ATCC BAA-1303) [Complete proteome] [HAMAP]
Taxonomic identifier322710 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_0000387620

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding162 – 1709NAD By similarity

Sites

Active site1311Acyl-thioester intermediate By similarity
Binding site2891NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
C1DRI9 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: B14C3AAC1683824A

FASTA31132,656
        10         20         30         40         50         60 
MKKLKVAIVG SGNIGTDLMI KILRHGQHLE MGALVGIDPD SDGLARAARL GVATTAEGVE 

        70         80         90        100        110        120 
GLARLPGFGE IDFVFDATSA AAHVKNDPFL RGLRPGLRLI DLTPAAVGPY CVPVVNLEQN 

       130        140        150        160        170        180 
LREPNVNMVT CGGQATIPMV AAVSRVARVH YAEIVASIAS RSAGPGTRAN IDEFTETTSK 

       190        200        210        220        230        240 
AIEAIGGARK GKAIIVLNPA EPPLIMRDTV YVLSAPADQA RVEASLAEMA QAVQGYVPGY 

       250        260        270        280        290        300 
RLKQRVQFDE IPDAAPLNIP GLGRLSGLKT SVFLEVEGAA HYLPAYAGNL DIMTSAALAT 

       310 
AERMAQSMLN A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001157 Genomic DNA. Translation: ACO77727.1.
RefSeqYP_002798702.1. NC_012560.1.

3D structure databases

ProteinModelPortalC1DRI9.
SMRC1DRI9. Positions 2-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING322710.Avin_15120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO77727; ACO77727; Avin_15120.
GeneID7760447.
KEGGavn:Avin_15120.
PATRIC21029311. VBIAzoVin72790_1438.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
OMAYVIPSIN.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycAVIN322710:GJ0M-1513-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_AZOVD
AccessionPrimary (citable) accession number: C1DRI9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families