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C1DRI9

- ACDH2_AZOVD

UniProt

C1DRI9 - ACDH2_AZOVD

Protein

Acetaldehyde dehydrogenase 2

Gene

mhpF

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
    Binding sitei289 – 2891NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi162 – 1709NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciAVIN322710:GJ0M-1513-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Name:mhpFUniRule annotation
    Ordered Locus Names:Avin_15120
    OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
    Taxonomic identifieri322710 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
    ProteomesiUP000002424: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Acetaldehyde dehydrogenase 2PRO_0000387620Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi322710.Avin_15120.

    Structurei

    3D structure databases

    ProteinModelPortaliC1DRI9.
    SMRiC1DRI9. Positions 2-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    OMAiYVIPSIN.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1DRI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKLKVAIVG SGNIGTDLMI KILRHGQHLE MGALVGIDPD SDGLARAARL    50
    GVATTAEGVE GLARLPGFGE IDFVFDATSA AAHVKNDPFL RGLRPGLRLI 100
    DLTPAAVGPY CVPVVNLEQN LREPNVNMVT CGGQATIPMV AAVSRVARVH 150
    YAEIVASIAS RSAGPGTRAN IDEFTETTSK AIEAIGGARK GKAIIVLNPA 200
    EPPLIMRDTV YVLSAPADQA RVEASLAEMA QAVQGYVPGY RLKQRVQFDE 250
    IPDAAPLNIP GLGRLSGLKT SVFLEVEGAA HYLPAYAGNL DIMTSAALAT 300
    AERMAQSMLN A 311
    Length:311
    Mass (Da):32,656
    Last modified:May 26, 2009 - v1
    Checksum:iB14C3AAC1683824A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001157 Genomic DNA. Translation: ACO77727.1.
    RefSeqiYP_002798702.1. NC_012560.1.

    Genome annotation databases

    EnsemblBacteriaiACO77727; ACO77727; Avin_15120.
    GeneIDi7760447.
    KEGGiavn:Avin_15120.
    PATRICi21029311. VBIAzoVin72790_1438.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001157 Genomic DNA. Translation: ACO77727.1 .
    RefSeqi YP_002798702.1. NC_012560.1.

    3D structure databases

    ProteinModelPortali C1DRI9.
    SMRi C1DRI9. Positions 2-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 322710.Avin_15120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO77727 ; ACO77727 ; Avin_15120 .
    GeneIDi 7760447.
    KEGGi avn:Avin_15120.
    PATRICi 21029311. VBIAzoVin72790_1438.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    OMAi YVIPSIN.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci AVIN322710:GJ0M-1513-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DJ / ATCC BAA-1303.

    Entry informationi

    Entry nameiACDH2_AZOVD
    AccessioniPrimary (citable) accession number: C1DRI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3