Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetaldehyde dehydrogenase 3

Gene

lapF

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei272NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADUniRule annotation4
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Name:lapF
Ordered Locus Names:Avin_30580
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
Proteomesi
  • UP000002424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876211 – 304Acetaldehyde dehydrogenase 3Add BLAST304

Proteomic databases

PRIDEiC1DN56

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_30580

Structurei

3D structure databases

ProteinModelPortaliC1DN56
SMRiC1DN56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK18366
OMAiGEHRTAP
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

C1DN56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIRCALIG SGNIGTDLIY KIRRSALLEP VWMVGIDPAS EGLARARELG
60 70 80 90 100
LKTTAEGVDG LLPHVQEDDI QIAFDATSAY VHAENSRKLN ALGVLVIDLT
110 120 130 140 150
PAAIGPLCVP PVNLREHAAR LEMNVNMISC AGQATIPVVH AVSRIQSVAY
160 170 180 190 200
AEIVASLASK SIGPGTRANL DEFTYTTSGA LEKVGGARRG KALAIINPAE
210 220 230 240 250
PPMIMRNTIS CLTDAEPDQE RLSASILQMV GEVQKYVPGY RLVNGPLYDG
260 270 280 290 300
NGVSVFMEVA GLGDYLPTYA GNLDIMTAAA TRTAEMFAEE ILAGKIRLPT

PEVA
Length:304
Mass (Da):32,308
Last modified:May 26, 2009 - v1
Checksum:i1D4C6F8C9D041824
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA Translation: ACO79223.1
RefSeqiWP_012701609.1, NC_012560.1

Genome annotation databases

EnsemblBacteriaiACO79223; ACO79223; Avin_30580
KEGGiavn:Avin_30580

Similar proteinsi

Entry informationi

Entry nameiACDH3_AZOVD
AccessioniPrimary (citable) accession number: C1DN56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health