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C1DN56

- ACDH3_AZOVD

UniProt

C1DN56 - ACDH3_AZOVD

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Protein

Acetaldehyde dehydrogenase 3

Gene

lapF

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
Binding sitei272 – 2721NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADUniRule annotation
Nucleotide bindingi161 – 1699NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-3061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Name:lapF
Ordered Locus Names:Avin_30580
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Acetaldehyde dehydrogenase 3PRO_0000387621Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_30580.

Structurei

3D structure databases

ProteinModelPortaliC1DN56.
SMRiC1DN56. Positions 2-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiDIQQYVP.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DN56 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIRCALIG SGNIGTDLIY KIRRSALLEP VWMVGIDPAS EGLARARELG
60 70 80 90 100
LKTTAEGVDG LLPHVQEDDI QIAFDATSAY VHAENSRKLN ALGVLVIDLT
110 120 130 140 150
PAAIGPLCVP PVNLREHAAR LEMNVNMISC AGQATIPVVH AVSRIQSVAY
160 170 180 190 200
AEIVASLASK SIGPGTRANL DEFTYTTSGA LEKVGGARRG KALAIINPAE
210 220 230 240 250
PPMIMRNTIS CLTDAEPDQE RLSASILQMV GEVQKYVPGY RLVNGPLYDG
260 270 280 290 300
NGVSVFMEVA GLGDYLPTYA GNLDIMTAAA TRTAEMFAEE ILAGKIRLPT

PEVA
Length:304
Mass (Da):32,308
Last modified:May 26, 2009 - v1
Checksum:i1D4C6F8C9D041824
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO79223.1.
RefSeqiYP_002800198.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO79223; ACO79223; Avin_30580.
GeneIDi7761958.
KEGGiavn:Avin_30580.
PATRICi21032274. VBIAzoVin72790_2890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO79223.1 .
RefSeqi YP_002800198.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DN56.
SMRi C1DN56. Positions 2-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_30580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO79223 ; ACO79223 ; Avin_30580 .
GeneIDi 7761958.
KEGGi avn:Avin_30580.
PATRICi 21032274. VBIAzoVin72790_2890.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi DIQQYVP.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci AVIN322710:GJ0M-3061-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiACDH3_AZOVD
AccessioniPrimary (citable) accession number: C1DN56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3