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C1DMV9

- SYL_AZOVD

UniProt

C1DMV9 - SYL_AZOVD

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-901-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Avin_09000
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Leucine--tRNA ligasePRO_1000202216Add
BLAST

Proteomic databases

PRIDEiC1DMV9.

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_09000.

Structurei

3D structure databases

ProteinModelPortaliC1DMV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi629 – 6335"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DMV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHEQYQPREI EAAAQSIWDA QKSFEVREQP GKDTFYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VIARYQRMQG RNVLQPMGWD AFGMPAENAA MKNRVAPAKW
110 120 130 140 150
TYENIAYMKS QLKSLGLGID WSREVTTCKP DYYRWEQWLF TRLFEKGVIY
160 170 180 190 200
RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYFRITAYAE
210 220 230 240 250
ELLQSLDSLP GWPEQVKTMQ RNWIGKSYGA DIVFDYDQAS VGEAGQLRVY
260 270 280 290 300
STRPDTLMGA TYVAVAAEHP LAQRAAANDP ALAAFIAECK AGSVAEADMA
310 320 330 340 350
TMEKKGLATG QFVVHPLTGD RLPVFVANYV LWGYGEGAVM AVPAHDERDF
360 370 380 390 400
EFANKYGLPI RQVYAAEGRD FSASEWQAWY ADKEGLTTVD SGKYDGKSFT
410 420 430 440 450
EAFDAIVADL EATGHGARKT QFRLRDWGIS RQRYWGCPIP IIHCEACGDV
460 470 480 490 500
PVPEEQLPVV LPEDVVPDGT GSPLAKMPEF YECACPKCGK PAKRETDTMD
510 520 530 540 550
TFVESSWYYA RYASPQYAGG MVDPQAADHW LPVDQYIGGI EHAILHLLYA
560 570 580 590 600
RFFHKLMRDE GLLSSDEPFE NLLTQGMVVA ETYYRTLENG GKDWFNPADV
610 620 630 640 650
EVERDARAKV IGARLKSDGL PVEIGGTEKM SKSKNNGVDP QAMIDAYGAD
660 670 680 690 700
TCRLFMMFAA PPELSLEWSD AGVEGASRFL RRVWRLAHAH VGAGLPGTLD
710 720 730 740 750
KARLSDAQKE IRRAIHLAIR QASQDVGQHH KFNTAIAQVM TLMNVLEKAP
760 770 780 790 800
AADEQDRALL QEGLETVALL LAPITPHICH ALWEALGKDG LIIDAAWPTV
810 820 830 840 850
DETALVQDTL TLVVQVNGKL RGEIQVPAAA SREEIEAAAR ANENVLRFTE
860 870
GLAIRKVIVV PGKLVNIVAN
Length:870
Mass (Da):96,892
Last modified:May 26, 2009 - v1
Checksum:iBD4A1F5526161760
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO77139.1.
RefSeqiYP_002798114.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO77139; ACO77139; Avin_09000.
GeneIDi7759848.
KEGGiavn:Avin_09000.
PATRICi21028097. VBIAzoVin72790_0841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO77139.1 .
RefSeqi YP_002798114.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DMV9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_09000.

Proteomic databases

PRIDEi C1DMV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO77139 ; ACO77139 ; Avin_09000 .
GeneIDi 7759848.
KEGGi avn:Avin_09000.
PATRICi 21028097. VBIAzoVin72790_0841.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AVIN322710:GJ0M-901-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiSYL_AZOVD
AccessioniPrimary (citable) accession number: C1DMV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3