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C1DMV9

- SYL_AZOVD

UniProt

C1DMV9 - SYL_AZOVD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei632 – 6321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAVIN322710:GJ0M-901-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Avin_09000
    OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
    Taxonomic identifieri322710 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
    ProteomesiUP000002424: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Leucine--tRNA ligasePRO_1000202216Add
    BLAST

    Proteomic databases

    PRIDEiC1DMV9.

    Interactioni

    Protein-protein interaction databases

    STRINGi322710.Avin_09000.

    Structurei

    3D structure databases

    ProteinModelPortaliC1DMV9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi629 – 6335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1DMV9-1 [UniParc]FASTAAdd to Basket

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    MHEQYQPREI EAAAQSIWDA QKSFEVREQP GKDTFYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VIARYQRMQG RNVLQPMGWD AFGMPAENAA MKNRVAPAKW 100
    TYENIAYMKS QLKSLGLGID WSREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
    RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYFRITAYAE 200
    ELLQSLDSLP GWPEQVKTMQ RNWIGKSYGA DIVFDYDQAS VGEAGQLRVY 250
    STRPDTLMGA TYVAVAAEHP LAQRAAANDP ALAAFIAECK AGSVAEADMA 300
    TMEKKGLATG QFVVHPLTGD RLPVFVANYV LWGYGEGAVM AVPAHDERDF 350
    EFANKYGLPI RQVYAAEGRD FSASEWQAWY ADKEGLTTVD SGKYDGKSFT 400
    EAFDAIVADL EATGHGARKT QFRLRDWGIS RQRYWGCPIP IIHCEACGDV 450
    PVPEEQLPVV LPEDVVPDGT GSPLAKMPEF YECACPKCGK PAKRETDTMD 500
    TFVESSWYYA RYASPQYAGG MVDPQAADHW LPVDQYIGGI EHAILHLLYA 550
    RFFHKLMRDE GLLSSDEPFE NLLTQGMVVA ETYYRTLENG GKDWFNPADV 600
    EVERDARAKV IGARLKSDGL PVEIGGTEKM SKSKNNGVDP QAMIDAYGAD 650
    TCRLFMMFAA PPELSLEWSD AGVEGASRFL RRVWRLAHAH VGAGLPGTLD 700
    KARLSDAQKE IRRAIHLAIR QASQDVGQHH KFNTAIAQVM TLMNVLEKAP 750
    AADEQDRALL QEGLETVALL LAPITPHICH ALWEALGKDG LIIDAAWPTV 800
    DETALVQDTL TLVVQVNGKL RGEIQVPAAA SREEIEAAAR ANENVLRFTE 850
    GLAIRKVIVV PGKLVNIVAN 870
    Length:870
    Mass (Da):96,892
    Last modified:May 26, 2009 - v1
    Checksum:iBD4A1F5526161760
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001157 Genomic DNA. Translation: ACO77139.1.
    RefSeqiYP_002798114.1. NC_012560.1.

    Genome annotation databases

    EnsemblBacteriaiACO77139; ACO77139; Avin_09000.
    GeneIDi7759848.
    KEGGiavn:Avin_09000.
    PATRICi21028097. VBIAzoVin72790_0841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001157 Genomic DNA. Translation: ACO77139.1 .
    RefSeqi YP_002798114.1. NC_012560.1.

    3D structure databases

    ProteinModelPortali C1DMV9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 322710.Avin_09000.

    Proteomic databases

    PRIDEi C1DMV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO77139 ; ACO77139 ; Avin_09000 .
    GeneIDi 7759848.
    KEGGi avn:Avin_09000.
    PATRICi 21028097. VBIAzoVin72790_0841.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci AVIN322710:GJ0M-901-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DJ / ATCC BAA-1303.

    Entry informationi

    Entry nameiSYL_AZOVD
    AccessioniPrimary (citable) accession number: C1DMV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3