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C1DMV9

- SYL_AZOVD

UniProt

C1DMV9 - SYL_AZOVD

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Protein
Leucine--tRNA ligase
Gene
leuS, Avin_09000
Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-901-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Avin_09000
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Leucine--tRNA ligaseUniRule annotation
PRO_1000202216Add
BLAST

Proteomic databases

PRIDEiC1DMV9.

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_09000.

Structurei

3D structure databases

ProteinModelPortaliC1DMV9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi629 – 6335"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DMV9-1 [UniParc]FASTAAdd to Basket

« Hide

MHEQYQPREI EAAAQSIWDA QKSFEVREQP GKDTFYCLSM FPYPSGKLHM    50
GHVRNYTIGD VIARYQRMQG RNVLQPMGWD AFGMPAENAA MKNRVAPAKW 100
TYENIAYMKS QLKSLGLGID WSREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYFRITAYAE 200
ELLQSLDSLP GWPEQVKTMQ RNWIGKSYGA DIVFDYDQAS VGEAGQLRVY 250
STRPDTLMGA TYVAVAAEHP LAQRAAANDP ALAAFIAECK AGSVAEADMA 300
TMEKKGLATG QFVVHPLTGD RLPVFVANYV LWGYGEGAVM AVPAHDERDF 350
EFANKYGLPI RQVYAAEGRD FSASEWQAWY ADKEGLTTVD SGKYDGKSFT 400
EAFDAIVADL EATGHGARKT QFRLRDWGIS RQRYWGCPIP IIHCEACGDV 450
PVPEEQLPVV LPEDVVPDGT GSPLAKMPEF YECACPKCGK PAKRETDTMD 500
TFVESSWYYA RYASPQYAGG MVDPQAADHW LPVDQYIGGI EHAILHLLYA 550
RFFHKLMRDE GLLSSDEPFE NLLTQGMVVA ETYYRTLENG GKDWFNPADV 600
EVERDARAKV IGARLKSDGL PVEIGGTEKM SKSKNNGVDP QAMIDAYGAD 650
TCRLFMMFAA PPELSLEWSD AGVEGASRFL RRVWRLAHAH VGAGLPGTLD 700
KARLSDAQKE IRRAIHLAIR QASQDVGQHH KFNTAIAQVM TLMNVLEKAP 750
AADEQDRALL QEGLETVALL LAPITPHICH ALWEALGKDG LIIDAAWPTV 800
DETALVQDTL TLVVQVNGKL RGEIQVPAAA SREEIEAAAR ANENVLRFTE 850
GLAIRKVIVV PGKLVNIVAN 870
Length:870
Mass (Da):96,892
Last modified:May 26, 2009 - v1
Checksum:iBD4A1F5526161760
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO77139.1.
RefSeqiYP_002798114.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO77139; ACO77139; Avin_09000.
GeneIDi7759848.
KEGGiavn:Avin_09000.
PATRICi21028097. VBIAzoVin72790_0841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO77139.1 .
RefSeqi YP_002798114.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DMV9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_09000.

Proteomic databases

PRIDEi C1DMV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO77139 ; ACO77139 ; Avin_09000 .
GeneIDi 7759848.
KEGGi avn:Avin_09000.
PATRICi 21028097. VBIAzoVin72790_0841.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AVIN322710:GJ0M-901-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiSYL_AZOVD
AccessioniPrimary (citable) accession number: C1DMV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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