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C1DMT1

- ACDH1_AZOVD

UniProt

C1DMT1 - ACDH1_AZOVD

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Protein

Acetaldehyde dehydrogenase 1

Gene

xylQ

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
Binding sitei289 – 2891NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NADUniRule annotation
Nucleotide bindingi164 – 1729NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Name:xylQ
Ordered Locus Names:Avin_08700
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Acetaldehyde dehydrogenase 1PRO_0000387619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_08700.

Structurei

3D structure databases

ProteinModelPortaliC1DMT1.
SMRiC1DMT1. Positions 5-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiIPEDADH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DMT1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRTSSRCKV AIIGSGNIGT DLMIKVLRHG RHLEMGAMVG IDPASDGLAR
60 70 80 90 100
AKRLGVATTA QGVEGLLALP EFKDIGIAFD ATSAGAHARH NELLQAHGVK
110 120 130 140 150
VIDLTPAAIG PYVVPAINLD AELDAPNINM VTCGGQATIP MVAAVSRVAQ
160 170 180 190 200
VHYAEIVASI ASKSAGPGTR ANIDEFTETT SKAIEVIGGA RKGKAIIVLN
210 220 230 240 250
PAEPPLIMRD SVFVLSEVVD RDAIAASVKE MVASVQRYVP GYRLKQEVQF
260 270 280 290 300
ELIEKPANVP GVGLVSGLKT SIFLEVEGAA HYLPAYAGNL DIMTSAALSC
310
AERLAERGKV RTLPSALV
Length:318
Mass (Da):33,304
Last modified:May 26, 2009 - v1
Checksum:i36FD96CC432BD85A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO77111.1.
RefSeqiYP_002798086.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO77111; ACO77111; Avin_08700.
GeneIDi7759820.
KEGGiavn:Avin_08700.
PATRICi21028045. VBIAzoVin72790_0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO77111.1 .
RefSeqi YP_002798086.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DMT1.
SMRi C1DMT1. Positions 5-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_08700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO77111 ; ACO77111 ; Avin_08700 .
GeneIDi 7759820.
KEGGi avn:Avin_08700.
PATRICi 21028045. VBIAzoVin72790_0815.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi IPEDADH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci AVIN322710:GJ0M-873-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiACDH1_AZOVD
AccessioniPrimary (citable) accession number: C1DMT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3