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C1DMT1 (ACDH1_AZOVD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Name:xylQ
Ordered Locus Names:Avin_08700
OrganismAzotobacter vinelandii (strain DJ / ATCC BAA-1303) [Complete proteome] [HAMAP]
Taxonomic identifier322710 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657
PRO_0000387619

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding164 – 1729NAD By similarity

Sites

Active site1331Acyl-thioester intermediate By similarity
Binding site2891NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
C1DMT1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 36FD96CC432BD85A

FASTA31833,304
        10         20         30         40         50         60 
MDRTSSRCKV AIIGSGNIGT DLMIKVLRHG RHLEMGAMVG IDPASDGLAR AKRLGVATTA 

        70         80         90        100        110        120 
QGVEGLLALP EFKDIGIAFD ATSAGAHARH NELLQAHGVK VIDLTPAAIG PYVVPAINLD 

       130        140        150        160        170        180 
AELDAPNINM VTCGGQATIP MVAAVSRVAQ VHYAEIVASI ASKSAGPGTR ANIDEFTETT 

       190        200        210        220        230        240 
SKAIEVIGGA RKGKAIIVLN PAEPPLIMRD SVFVLSEVVD RDAIAASVKE MVASVQRYVP 

       250        260        270        280        290        300 
GYRLKQEVQF ELIEKPANVP GVGLVSGLKT SIFLEVEGAA HYLPAYAGNL DIMTSAALSC 

       310 
AERLAERGKV RTLPSALV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001157 Genomic DNA. Translation: ACO77111.1.
RefSeqYP_002798086.1. NC_012560.1.

3D structure databases

ProteinModelPortalC1DMT1.
SMRC1DMT1. Positions 5-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING322710.Avin_08700.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO77111; ACO77111; Avin_08700.
GeneID7759820.
KEGGavn:Avin_08700.
PATRIC21028045. VBIAzoVin72790_0815.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAIPEDADH.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycAVIN322710:GJ0M-873-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_AZOVD
AccessionPrimary (citable) accession number: C1DMT1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families