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C1DMT1

- ACDH1_AZOVD

UniProt

C1DMT1 - ACDH1_AZOVD

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Protein
Acetaldehyde dehydrogenase 1
Gene
xylQ, Avin_08700
Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediate By similarity
Binding sitei289 – 2891NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NAD By similarity
Nucleotide bindingi164 – 1729NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene namesi
Name:xylQ
Ordered Locus Names:Avin_08700
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Acetaldehyde dehydrogenase 1UniRule annotation
PRO_0000387619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_08700.

Structurei

3D structure databases

ProteinModelPortaliC1DMT1.
SMRiC1DMT1. Positions 5-306.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiIPEDADH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DMT1-1 [UniParc]FASTAAdd to Basket

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MDRTSSRCKV AIIGSGNIGT DLMIKVLRHG RHLEMGAMVG IDPASDGLAR    50
AKRLGVATTA QGVEGLLALP EFKDIGIAFD ATSAGAHARH NELLQAHGVK 100
VIDLTPAAIG PYVVPAINLD AELDAPNINM VTCGGQATIP MVAAVSRVAQ 150
VHYAEIVASI ASKSAGPGTR ANIDEFTETT SKAIEVIGGA RKGKAIIVLN 200
PAEPPLIMRD SVFVLSEVVD RDAIAASVKE MVASVQRYVP GYRLKQEVQF 250
ELIEKPANVP GVGLVSGLKT SIFLEVEGAA HYLPAYAGNL DIMTSAALSC 300
AERLAERGKV RTLPSALV 318
Length:318
Mass (Da):33,304
Last modified:May 26, 2009 - v1
Checksum:i36FD96CC432BD85A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO77111.1.
RefSeqiYP_002798086.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO77111; ACO77111; Avin_08700.
GeneIDi7759820.
KEGGiavn:Avin_08700.
PATRICi21028045. VBIAzoVin72790_0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO77111.1 .
RefSeqi YP_002798086.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DMT1.
SMRi C1DMT1. Positions 5-306.
ModBasei Search...

Protein-protein interaction databases

STRINGi 322710.Avin_08700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO77111 ; ACO77111 ; Avin_08700 .
GeneIDi 7759820.
KEGGi avn:Avin_08700.
PATRICi 21028045. VBIAzoVin72790_0815.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi IPEDADH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci AVIN322710:GJ0M-873-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiACDH1_AZOVD
AccessioniPrimary (citable) accession number: C1DMT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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