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C1DM03

- GCH4_AZOVD

UniProt

C1DM03 - GCH4_AZOVD

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-2923-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Avin_29210
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2PRO_1000215385Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_29210.

Structurei

3D structure databases

ProteinModelPortaliC1DM03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DM03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIPLPDVAL TELSATRAPL DWVGMDGIDV PILLDEPEFA YPVHARAEVQ
60 70 80 90 100
VDLPDPAIKG IHMSRLYRLL DGFAGRDRLN PASLAVLLRE MVFSHADCNS
110 120 130 140 150
TRARLTLAFS LLCRRPALLT QGLSGWKSYP VRLEAVWEAG RLSLDATLQI
160 170 180 190 200
GYSSTCPCSA ALTRQLIEQA FVERFSAAGQ VEPAAVAAWL QRNATLATPH
210 220 230 240 250
SQRSVAEVRV RIPEGATRLG LLALIERIET CLGTPVQTAV KRADEQAFAR
260 270 280 290
LNGQNLMYVE DAARKIRQAV AEGFSQFSVS VRHVESLHPH DAVASSSS
Length:298
Mass (Da):32,517
Last modified:May 26, 2009 - v1
Checksum:i77E28242996E145F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO79090.1.
RefSeqiYP_002800065.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO79090; ACO79090; Avin_29210.
GeneIDi7761824.
KEGGiavn:Avin_29210.
PATRICi21031995. VBIAzoVin72790_2755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO79090.1 .
RefSeqi YP_002800065.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DM03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_29210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO79090 ; ACO79090 ; Avin_29210 .
GeneIDi 7761824.
KEGGi avn:Avin_29210.
PATRICi 21031995. VBIAzoVin72790_2755.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi QNLMYVE.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci AVIN322710:GJ0M-2923-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiGCH4_AZOVD
AccessioniPrimary (citable) accession number: C1DM03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3