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C1DLJ1 (PUR9_AZOVD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Avin_06890
OrganismAzotobacter vinelandii (strain DJ / ATCC BAA-1303) [Complete proteome] [HAMAP]
Taxonomic identifier322710 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000203246

Sequences

Sequence LengthMass (Da)Tools
C1DLJ1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: B999CEBB74DF600C

FASTA53557,290
        10         20         30         40         50         60 
MTDQTTRLPV RRALISVSDK TGVVDFAREL AALGVEILST GGTFKLLREH GVDAVEVADY 

        70         80         90        100        110        120 
TGFPEMMDGR VKTLHPKIHG GILGRRDLDA AVMAEHGIQP IDLVAVNLYP FAATVARPGC 

       130        140        150        160        170        180 
TLAEAIENID IGGPTMVRSA AKNHKDVAIV VNAADYAGVL ESLKNGGLTY AQRFDLALRA 

       190        200        210        220        230        240 
FEHTAAYDGM IANYLGTIDQ GAETLTTEGR AAFPRTFNSQ FVKAQDMRYG ENPHQQAAFY 

       250        260        270        280        290        300 
VETSPAEASV ATARQLQGKE LSYNNVADTD AALECVKSFV KPACVIVKHA NPCGVAVVPE 

       310        320        330        340        350        360 
DEGGIRKAYD LAYATDSESA FGGIIAFNRE LDGATARAIV ERQFVEVIIA PSVSAEAREA 

       370        380        390        400        410        420 
VAAKANVRLL ECGQWPAERA DGLDFKRVNG GLLVQSRDIG MIAEADLKVV TRRAPTEREI 

       430        440        450        460        470        480 
HDLIFAWKVA KFVKSNAIVY ARNRQTIGVG AGQMSRVNSA RIAAIKAEHA GLEVAGAVMA 

       490        500        510        520        530 
SDAFFPFRDG IDNAAKAGIT AVIQPGGSMR DNEVIAAADE AGMAMVFTGM RHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001157 Genomic DNA. Translation: ACO76939.1.
RefSeqYP_002797914.1. NC_012560.1.

3D structure databases

ProteinModelPortalC1DLJ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING322710.Avin_06890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO76939; ACO76939; Avin_06890.
GeneID7759642.
KEGGavn:Avin_06890.
PATRIC21027699. VBIAzoVin72790_0644.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycAVIN322710:GJ0M-693-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_AZOVD
AccessionPrimary (citable) accession number: C1DLJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways