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Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-5002-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:Avin_50110
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
Proteomesi
  • UP000002424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Inositol 2-dehydrogenasePRO_1000215883Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi322710.Avin_50110.

Structurei

3D structure databases

ProteinModelPortaliC1DLA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DRI. Bacteria.
COG0673. LUCA.
HOGENOMiHOG000227439.
KOiK00010.
OMAiATVYPND.
OrthoDBiEOG6GFGMS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DLA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNIGVIGT GAIGQDHIRR CSFALSGAKV VAVNDINLEQ AKKVVNDLGI
60 70 80 90 100
GAEVYADAHE LINAANVEAI LVTSWGPTHE EFVLAAIKAG KPVFCEKPLA
110 120 130 140 150
VTAQGCKNIV DAETAFGKRL VQVGFMRPYD QGYRALKAVI DSGRIGEPLM
160 170 180 190 200
LHCAHRNARV GQAYATDMAI TDTLIHEINV LSWLLDDHYV SAQVIFPRKS
210 220 230 240 250
ARALAHLKDP QIVLLETAKG TRIDVEVFVN CQYGYDIQCE VVGETGIARL
260 270 280 290 300
PEPSSVQLRS EARLSNEILV DWKDRFIAAY DVELQDFIDA VGAGRLTGPS
310 320 330
AWDGYTAAVT ADACVAAQGS GKVEPIVLPE RPAFYAPA
Length:338
Mass (Da):36,483
Last modified:May 26, 2009 - v1
Checksum:iAD49F1692E371A8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO81101.1.
RefSeqiWP_012703454.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO81101; ACO81101; Avin_50110.
KEGGiavn:Avin_50110.
PATRICi21036023. VBIAzoVin72790_4734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO81101.1.
RefSeqiWP_012703454.1. NC_012560.1.

3D structure databases

ProteinModelPortaliC1DLA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_50110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO81101; ACO81101; Avin_50110.
KEGGiavn:Avin_50110.
PATRICi21036023. VBIAzoVin72790_4734.

Phylogenomic databases

eggNOGiENOG4105DRI. Bacteria.
COG0673. LUCA.
HOGENOMiHOG000227439.
KOiK00010.
OMAiATVYPND.
OrthoDBiEOG6GFGMS.

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-5002-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiIOLG_AZOVD
AccessioniPrimary (citable) accession number: C1DLA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: December 9, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.