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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

Avin_23510

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511SuccinateCombined sources
Binding sitei97 – 971SuccinateCombined sources

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotation

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-2350-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Gene namesi
Ordered Locus Names:Avin_23510Imported
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)Imported
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_23510.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T1UX-ray2.00A2-163[»]
SMRiC1DHE4. Positions 1-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation
Contains 1 PPIase cyclophilin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065978.
KOiK03768.
OMAiTVVQEWG.
OrthoDBiEOG6S26C3.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DHE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLQTNHGT ITLKLFADKA PETAANFEQY VKDGHYDGTI FHRVIDGFMI
60 70 80 90 100
QGGGFEPGMK QKSTRAPIKN EANNGLSNKK YTIAMARTPD PHSASAQFFI
110 120 130 140 150
NVKDNAFLDH TAPTAHGWGY AVFGEVVEGT DVVDRIKSVA TGSRAGHGDV
160
PVDDVIIEKA EIVE
Length:164
Mass (Da):17,831
Last modified:May 26, 2009 - v1
Checksum:iA7C2E78E0943ABC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO78539.1.
RefSeqiYP_002799514.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO78539; ACO78539; Avin_23510.
KEGGiavn:Avin_23510.
PATRICi21030925. VBIAzoVin72790_2232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO78539.1.
RefSeqiYP_002799514.1. NC_012560.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T1UX-ray2.00A2-163[»]
SMRiC1DHE4. Positions 1-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_23510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO78539; ACO78539; Avin_23510.
KEGGiavn:Avin_23510.
PATRICi21030925. VBIAzoVin72790_2232.

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065978.
KOiK03768.
OMAiTVVQEWG.
OrthoDBiEOG6S26C3.

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-2350-MONOMER.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303Imported.
  2. "Structure of a bacterial cytoplasmic cyclophilin A in complex with a tetrapeptide."
    Christoforides E., Dimou M., Katinakis P., Bethanis K., Karpusas M.
    Acta Crystallogr. F 68:259-264(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-163 IN COMPLEX WITH SUCCINATE.

Entry informationi

Entry nameiC1DHE4_AZOVD
AccessioniPrimary (citable) accession number: C1DHE4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.