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C1DFK2

- C1DFK2_AZOVD

UniProt

C1DFK2 - C1DFK2_AZOVD

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Protein

Acetyl-coenzyme A synthetase

Gene
acsA, acsA2, Avin_42750
Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei308 – 3081Coenzyme A By similarityUniRule annotation
Binding sitei332 – 3321Coenzyme A By similarityUniRule annotation
Binding sitei384 – 3841Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei497 – 4971Substrate By similarityUniRule annotation
Binding sitei512 – 5121Substrate By similarityUniRule annotation
Active sitei514 – 5141 By similarityUniRule annotation
Binding sitei520 – 5201Coenzyme A By similarityUniRule annotation
Binding sitei523 – 5231Substrate By similarityUniRule annotation
Metal bindingi534 – 5341Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi536 – 5361Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi539 – 5391Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei581 – 5811Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-4277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsAUniRule annotation
Synonyms:acsA2Imported
Ordered Locus Names:Avin_42750Imported
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)Imported
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
ProteomesiUP000002424: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei606 – 6061N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_42750.

Structurei

3D structure databases

ProteinModelPortaliC1DFK2.
SMRiC1DFK2. Positions 7-642.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni408 – 4136Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiKSLENPE.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DFK2-1 [UniParc]FASTAAdd to Basket

« Hide

MFKIANHPVS EALRQHSWLN NDDYLRLYRQ SVEQPDSFWA EQATLFLDWF    50
KPWRNIHRGD MNKGEIHWFE GSQLNVAHNC IDRHLKQRGD QVAIIWEGDN 100
PADSARITYR QLHEQVCRLA NLLKSRGIGK GDRVCIYMPM IPEAAYAMLA 150
CARIGAVHSV VFGGFSPEAL RDRILDADCR LLITADESVR GGKVVPLKRN 200
ADKALQSCSG VSSVIVVRRT GGAIDWNVGR DLWYHEAVPG CSADCPAEPM 250
DAEAPLFILY TSGSTGKPKG VLHTTGGYLL QAAMTHQYVF DYHDGDIYWC 300
SADIGWITGH SYIVYGPLAN GATTLIFEGV PNYPDASRFW QVVDKHRVNI 350
FYTAPTALRS LMREGEGPVR KTSRASLRLL GSVGEPINPE AWEWYYHVVG 400
DSRCPIVDTW WQTETGAIMI TPLPGATLLK PGSATRPFFG VQPVLLDDKG 450
KEIEGPGAGI LAIKASWPSQ IRSIYGDHQR LIDTYFKPCP GYYFTGDGAR 500
RDEDGYYWIT GRVDDVINVS GHRIGTAEVE SALVLHDSIA EAAVVGCPHD 550
VKGQCVYAFV TLVTGSRPSD QLKRELIDQV SREIGGFAKP DFLQWAPRLP 600
KTRSGKIMRR ILRKIACNEL DNLGDTSTLS DPSVLQELID NRLSH 645
Length:645
Mass (Da):71,897
Last modified:May 26, 2009 - v1
Checksum:i2196F80A1AE5C342
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO80398.1.
RefSeqiYP_002801373.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO80398; ACO80398; Avin_42750.
GeneIDi7763150.
KEGGiavn:Avin_42750.
PATRICi21034580. VBIAzoVin72790_4023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001157 Genomic DNA. Translation: ACO80398.1 .
RefSeqi YP_002801373.1. NC_012560.1.

3D structure databases

ProteinModelPortali C1DFK2.
SMRi C1DFK2. Positions 7-642.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322710.Avin_42750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO80398 ; ACO80398 ; Avin_42750 .
GeneIDi 7763150.
KEGGi avn:Avin_42750.
PATRICi 21034580. VBIAzoVin72790_4023.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi KSLENPE.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci AVIN322710:GJ0M-4277-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJ / ATCC BAA-1303.

Entry informationi

Entry nameiC1DFK2_AZOVD
AccessioniPrimary (citable) accession number: C1DFK2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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