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C1DF11

- ACDH4_AZOVD

UniProt

C1DF11 - ACDH4_AZOVD

Protein

Acetaldehyde dehydrogenase 4

Gene

Avin_42130

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321Acyl-thioester intermediateUniRule annotation
    Binding sitei290 – 2901NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADUniRule annotation
    Nucleotide bindingi163 – 1719NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciAVIN322710:GJ0M-4211-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 4UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 4UniRule annotation
    Gene namesi
    Ordered Locus Names:Avin_42130
    OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
    Taxonomic identifieri322710 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
    ProteomesiUP000002424: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Acetaldehyde dehydrogenase 4PRO_0000387622Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi322710.Avin_42130.

    Structurei

    3D structure databases

    ProteinModelPortaliC1DF11.
    SMRiC1DF11. Positions 1-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiFTETTAH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1DF11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKKLKVAIV GSGNIGTDLM IKILRHGQHL EMGALVGIDP NSDGLARAAR    50
    LGVATTAEGV EGLARLPGFG EIDFVFDATS AGAHVRNEAF LRALKPGLRL 100
    IDLTPAAIGP YCVPVVNLEQ NLHETNVNMV TCGGQATIPM VAAVSRVARV 150
    HYAEIVASIA SRSAGPGTRA NIDEFTETTS KAIEAIGGAR KGKAIIVLNP 200
    AEPPLIMRDT VYVLSAPADR ARVEASLAEM AQAVQGYVPG YRLKQRVQFD 250
    EIPDAAPLNI PGLGRLSGLK TSVFLEVEGA AHYLPAYAGN LDIMTSAALA 300
    TAERMAQSML NA 312
    Length:312
    Mass (Da):32,771
    Last modified:May 26, 2009 - v1
    Checksum:i0E27C1810950BD4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001157 Genomic DNA. Translation: ACO80340.1.
    RefSeqiYP_002801315.1. NC_012560.1.

    Genome annotation databases

    EnsemblBacteriaiACO80340; ACO80340; Avin_42130.
    GeneIDi7763091.
    KEGGiavn:Avin_42130.
    PATRICi21034450. VBIAzoVin72790_3964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001157 Genomic DNA. Translation: ACO80340.1 .
    RefSeqi YP_002801315.1. NC_012560.1.

    3D structure databases

    ProteinModelPortali C1DF11.
    SMRi C1DF11. Positions 1-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 322710.Avin_42130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO80340 ; ACO80340 ; Avin_42130 .
    GeneIDi 7763091.
    KEGGi avn:Avin_42130.
    PATRICi 21034450. VBIAzoVin72790_3964.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi FTETTAH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci AVIN322710:GJ0M-4211-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DJ / ATCC BAA-1303.

    Entry informationi

    Entry nameiACDH4_AZOVD
    AccessioniPrimary (citable) accession number: C1DF11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3