Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831S-adenosyl-L-methionineUniRule annotation
Binding sitei235 – 2351S-adenosyl-L-methionineUniRule annotation
Binding sitei255 – 2551S-adenosyl-L-methionineUniRule annotation
Binding sitei271 – 2711S-adenosyl-L-methionineUniRule annotation
Active sitei300 – 3001Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-2014-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:Avin_20050
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
Proteomesi
  • UP000002424 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Ribosomal RNA large subunit methyltransferase MPRO_1000215467Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi322710.Avin_20050.

Structurei

3D structure databases

ProteinModelPortaliC1DEM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 2194S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiPOG091H04R8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DEM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLLLHCRP GFEGEVCAEI GEHAGRLNVA GYARAKPNSA HAEFVCSEPG
60 70 80 90 100
GAERLMRELR FAGLVFPRQW ARGAFVELPE SERIGVLLEH LAAYPVCGSL
110 120 130 140 150
WLEVLDSNEG KELSTFCRKF EVPLRKALGK TGRLLDDPRR PRLLLTFRSG
160 170 180 190 200
REVFLGLAEP DNSAAWPMGI PRLKFPREAP SRSTLKLEEA WHQFIPREAW
210 220 230 240 250
DLRLAPGMSA VDLGAAPGGW TWQLVNRHMK VTAVDNGPMA QSLMDSGLVE
260 270 280 290 300
HVRADGFVFR PRRPVDWMVC DIVEKPARTA ALIETWLGEG LCREAVVNLK
310 320 330 340 350
LPMKQRHAEV RRLLERIRDG LSARGAKVSV ACRQLYHDRE EVTCHLCRLP

APA
Length:353
Mass (Da):39,544
Last modified:May 26, 2009 - v1
Checksum:iF3460C057E261AE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO78212.1.
RefSeqiWP_012700621.1. NC_012560.1.

Genome annotation databases

EnsemblBacteriaiACO78212; ACO78212; Avin_20050.
KEGGiavn:Avin_20050.
PATRICi21030263. VBIAzoVin72790_1904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA. Translation: ACO78212.1.
RefSeqiWP_012700621.1. NC_012560.1.

3D structure databases

ProteinModelPortaliC1DEM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_20050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO78212; ACO78212; Avin_20050.
KEGGiavn:Avin_20050.
PATRICi21030263. VBIAzoVin72790_1904.

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiPOG091H04R8.

Enzyme and pathway databases

BioCyciAVIN322710:GJ0M-2014-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMM_AZOVD
AccessioniPrimary (citable) accession number: C1DEM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: September 7, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.