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C1DC84

- PUR5_LARHH

UniProt

C1DC84 - PUR5_LARHH

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLHON557598:GHO5-515-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:LHK_00508
OrganismiLaribacter hongkongensis (strain HLHK9)
Taxonomic identifieri557598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
ProteomesiUP000002010: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212826Add
BLAST

Proteomic databases

PRIDEiC1DC84.

Interactioni

Protein-protein interaction databases

STRINGi557598.LHK_00508.

Structurei

3D structure databases

ProteinModelPortaliC1DC84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C1DC84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQSLSYRDA GVDIDAGDQL VENIKPFAKR TMRPEVLGGL GGFGALVEIS
60 70 80 90 100
KKYREPVLVS GTDGVGTKLK LAFDWNRHDT VGIDLVAMSV NDILVQGAEP
110 120 130 140 150
LFFLDYFACG KLDVAQATDV IKGIAEGCEQ AGCALIGGET AEMPGMYPVG
160 170 180 190 200
EYDLAGFAVG VVEKSQVITG RDIRPGDVVL GLGSNGVHSN GFSLVRKIIE
210 220 230 240 250
RAGPDLDAPF DGDRTLRDAI IAPTRIYVKP LLKLMAGVPV KGMAHITGGG
260 270 280 290 300
ITENTPRVLP DNCVAQIDAA SWTLPKLFQW LQQEGNVDAQ EMYRTFNCGI
310 320 330 340
GMVVIVAPEQ ADAATALLTA EGETVHRLGL VRARQGDEHQ TQIA
Length:344
Mass (Da):36,706
Last modified:May 26, 2009 - v1
Checksum:iE5FCCA8DB3216A30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO73501.1.
RefSeqiWP_012695993.1. NC_012559.1.
YP_002794510.1. NC_012559.1.

Genome annotation databases

EnsemblBacteriaiACO73501; ACO73501; LHK_00508.
GeneIDi7756131.
KEGGilhk:LHK_00508.
PATRICi22298111. VBILarHon49832_0479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO73501.1 .
RefSeqi WP_012695993.1. NC_012559.1.
YP_002794510.1. NC_012559.1.

3D structure databases

ProteinModelPortali C1DC84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557598.LHK_00508.

Proteomic databases

PRIDEi C1DC84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO73501 ; ACO73501 ; LHK_00508 .
GeneIDi 7756131.
KEGGi lhk:LHK_00508.
PATRICi 22298111. VBILarHon49832_0479.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LHON557598:GHO5-515-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
    Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
    PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLHK9.

Entry informationi

Entry nameiPUR5_LARHH
AccessioniPrimary (citable) accession number: C1DC84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3