C1DB78 (C1DB78_LARHH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Catalase-peroxidase 2 HAMAP MF_01961
Short name=CP 2 HAMAP MF_01961
EC=1.11.1.21 HAMAP MF_01961

Alternative name(s):
Peroxidase/catalase 2 HAMAP MF_01961

Gene names

Name:	katG2 HAMAP MF_01961
Ordered Locus Names:	LHK_02436

Organism

Laribacter hongkongensis (strain HLHK9) [Complete proteome] [HAMAP]

Taxonomic identifier

557598 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Laribacter

Protein attributes

Sequence length	724 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961
Catalytic activity	2 H2O2 = O2 + 2 H2O. RuleBase RU003451 HAMAP MF_01961 SAAS SAAS019794 Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961 SAAS SAAS019794
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity. HAMAP MF_01961
Subunit structure	Homodimer or homotetramer By similarity. HAMAP MF_01961
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily. RuleBase RU003451 HAMAP MF_01961

Ontologies

Keywords
Biological process	Hydrogen peroxide RuleBase RU003451 HAMAP MF_01961 SAAS SAAS019794
Ligand	Heme HAMAP MF_01961 RuleBase RU003900 SAAS SAAS000763 Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: HAMAP heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	99	1	Proton acceptor By similarity HAMAP MF_01961
	Metal binding	267	1	Iron (heme axial ligand) By similarity HAMAP MF_01961
	Site	95	1	Transition state stabilizer By similarity HAMAP MF_01961
Amino acid modifications
	Cross-link	98 ↔ 226		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252) By similarity HAMAP MF_01961
	Cross-link	226 ↔ 252		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98) By similarity HAMAP MF_01961

Sequences

	Sequence		Length	Mass (Da)
	C1DB78 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 87921CB97BDB4921	FASTA	724	80,054
	10 20 30 40 50 60 MESKGVNVAG KCPVMHGGLT SASMSNMDWW PKALNLDILH QHDSKTNPMG AGFNYREEVR 70 80 90 100 110 120 KLDVEALKAD LKALMTDSQD WWPADWGHYG GLMIRMAWHS AGTYRTADGR GGGGTANQRF 130 140 150 160 170 180 APINSWPDNA NLDKARRLLW PVKKKYGNKI SWADLIILAG TMAYESMGLK TFGFGFGRED 190 200 210 220 230 240 IWHPEKDTYW GSEKEWLAPS GSEGSRYSGE RDLENPLAAV MMGLIYVNPE GVDGQPDPLK 250 260 270 280 290 300 TARDMRITFA RMAMDDEETV ALTAGGHTVG KCHGNGNAAN LGPAPEGAGL EEQGLGWMNH 310 320 330 340 350 360 TTRGCGRDAV TSGIEGAWTT HPARWDNGYF SMLLDHDWWL HKSPAGAWQW EPVSIREEDM 370 380 390 400 410 420 PVDVEDPSIR RKPIMTDADM ALKFDPEYRR IADRFRQDQA YFSEVFARAW FKLTHRDMGP 430 440 450 460 470 480 KARYIGPDVP AEDLIWQDPV PSGRKDYDVA AVKAKIAAAG LSVSDMVSTA WDSARTFRGS 490 500 510 520 530 540 DKRGGANGAR IRLAPQKDWE GNEPARLARV LAVYETVARE CGVSVADVIV LGGSLGIEQA 550 560 570 580 590 600 AAAAGISIHV PFSPGRGDAT DEMTDAASFD VLEPLADGFR NWLKKDYVVS AEELLLDRAQ 610 620 630 640 650 660 LMRLTACEMT VLVGGMRVLG TNHGGTQHGV LTDRVGVLSN DFFVNLTDMA FSWQPAGSNL 670 680 690 700 710 720 YEIRDRRTGT VKWTASRVDL VFGSNSVLRA YAEVYAQDDN REKFVRDFVA AWVKVMNADR FDLN

References

[1]

"The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats." Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y. PLoS Genet. 5:E1000416-E1000416(2009) [PubMed: 19283063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001154 Genomic DNA. Translation: ACO75418.1.
RefSeq	YP_002796426.1. NC_012559.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C1DB78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7758046.
GenomeReviews	Gene locus LHK_02436 in contig CP001154_GR.
KEGG	lhk:LHK_02436.
PATRIC	22301691. VBILarHon49832_2227.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	WPNALNL.
ProtClustDB	PRK15061.
Family and domain databases
HAMAP	MF_01961. Catal_peroxid. [Tree]
InterPro	IPR000763. Catalase_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. [Graphical view]
KO	K03782.
Pfam	PF00141. peroxidase. 2 hits. [Graphical view]
PRINTS	PR00460. BPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 2 hits.
TIGRFAMs	TIGR00198. Cat_per_HPI. 1 hit.
PROSITE	PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C1DB78_LARHH

Accession

Primary (citable) accession number: C1DB78

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)