C1DAF0 (C1DAF0_LARHH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523
EC=2.3.1.- HAMAP MF_00523

Gene names

Name:	lpxD HAMAP MF_00523
Ordered Locus Names:	LHK_02281

Organism

Laribacter hongkongensis (strain HLHK9) [Complete proteome] [HAMAP]

Taxonomic identifier

557598 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Laribacter

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523 UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. SAAS SAAS020573
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523 Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. SAAS SAAS020573
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily. HAMAP MF_00523

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00523 SAAS SAAS020573 Lipid synthesis
Domain	Repeat HAMAP MF_00523 SAAS SAAS020573
Molecular function	Acyltransferase HAMAP MF_00523 SAAS SAAS020573 EMBL ACO75265.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C1DAF0 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: EE59F1CF0F04A9A5	FASTA	346	35,869
	10 20 30 40 50 60 MNGLTLGDIV DRLGGELCGE GSLLIERVAA LETAGEGDIA FVTAKHAAAG HASSASALIV 70 80 90 100 110 120 PVALAGQFAA THIACRDPQL YFARVATLFH PLPTARPGIH PSAVVSPSAS LAPGVEVGPH 130 140 150 160 170 180 VVIGDHAVIG EGVILSAGSF VGEGARIGSA TILYARAVVE HHCVVGEHCI LHPGCVIGAD 190 200 210 220 230 240 GFGNAFAGDH WEKIPQIGRV IIGNSVEIGA NTTVDRGALA DTVIEDGVRL DNLIHIAHNC 250 260 270 280 290 300 HIGRHTAMAA CVGVAGSTRM GAYCLVGGAG MVSGHLDIGD RVQISGGTLV AKSIRKPGVY 310 320 330 340 TAVYPLAEHK EWLTNAARVR QLDSLFSRVK ELERELDELK NSEKCK

References

[1]

"The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats." Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y. PLoS Genet. 5:E1000416-E1000416(2009) [PubMed: 19283063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001154 Genomic DNA. Translation: ACO75265.1.
RefSeq	YP_002796274.1. NC_012559.1.
3D structure databases
ProteinModelPortal	C1DAF0.
ModBase	Search...
Protein-protein interaction databases
STRING	C1DAF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7757894.
GenomeReviews	Gene locus LHK_02281 in contig CP001154_GR.
KEGG	lhk:LHK_02281.
PATRIC	22301395. VBILarHon49832_2086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CFVGKNT.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C1DAF0_LARHH

Accession

Primary (citable) accession number: C1DAF0

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)