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C1DA41 (ILVC_LARHH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:LHK_00158
OrganismLaribacter hongkongensis (strain HLHK9) [Complete proteome] [HAMAP]
Taxonomic identifier557598 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase HAMAP-Rule MF_00435
PRO_1000190973

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
C1DA41 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 1EA5FEDCE2B4AFFC

FASTA33836,701
        10         20         30         40         50         60 
MKVYYDKDAD LSIIRDKKVA IIGYGSQGHA HAQNLKESGV DVIVGLRKDG ASWKKAEAAG 

        70         80         90        100        110        120 
HTVKEVGEAV KTADVVMILL PDETQPDVYR NDIAPNLKKG AALAFAHGFN IHYNQIVPPA 

       130        140        150        160        170        180 
DIDVIMIAPK GPGHTVRSEF LKGGGVPSLI AVYQDHSGRA RDVALSYAAA NGGTKGGVIE 

       190        200        210        220        230        240 
TSFREETETD LFGEQAVLCG GAVELVKAGF ETLTEAGYAP EMAYFECLHE LKLIVDLMYE 

       250        260        270        280        290        300 
GGIANMNYSI SNNAEYGEYV TGPEVITAAS KEAMKKALYR IQSGEYAKMF ILEGKTNYPS 

       310        320        330 
MTARRRLTAD HPIEKVGAEL RAMMPWIAKN KLVDQSKN 

« Hide

References

[1]"The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HLHK9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001154 Genomic DNA. Translation: ACO73154.1.
RefSeqYP_002794163.1. NC_012559.1.

3D structure databases

ProteinModelPortalC1DA41.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING557598.LHK_00158.

Proteomic databases

PRIDEC1DA41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO73154; ACO73154; LHK_00158.
GeneID7755786.
KEGGlhk:LHK_00158.
PATRIC22297443. VBILarHon49832_0157.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHOG000016230.
KOK00053.
OMARFAKDFI.
OrthoDBEOG625K07.

Enzyme and pathway databases

BioCycLHON557598:GHO5-158-MONOMER.
UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_LARHH
AccessionPrimary (citable) accession number: C1DA41
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways