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C1DA41

- ILVC_LARHH

UniProt

C1DA41 - ILVC_LARHH

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei107 – 1071UniRule annotation

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciLHON557598:GHO5-158-MONOMER.
    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductaseUniRule annotation
    Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
    Gene namesi
    Name:ilvCUniRule annotation
    Ordered Locus Names:LHK_00158
    OrganismiLaribacter hongkongensis (strain HLHK9)
    Taxonomic identifieri557598 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
    ProteomesiUP000002010: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Ketol-acid reductoisomerasePRO_1000190973Add
    BLAST

    Proteomic databases

    PRIDEiC1DA41.

    Interactioni

    Protein-protein interaction databases

    STRINGi557598.LHK_00158.

    Structurei

    3D structure databases

    ProteinModelPortaliC1DA41.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0059.
    HOGENOMiHOG000016230.
    KOiK00053.
    OMAiRFAKDFI.
    OrthoDBiEOG625K07.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1DA41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVYYDKDAD LSIIRDKKVA IIGYGSQGHA HAQNLKESGV DVIVGLRKDG    50
    ASWKKAEAAG HTVKEVGEAV KTADVVMILL PDETQPDVYR NDIAPNLKKG 100
    AALAFAHGFN IHYNQIVPPA DIDVIMIAPK GPGHTVRSEF LKGGGVPSLI 150
    AVYQDHSGRA RDVALSYAAA NGGTKGGVIE TSFREETETD LFGEQAVLCG 200
    GAVELVKAGF ETLTEAGYAP EMAYFECLHE LKLIVDLMYE GGIANMNYSI 250
    SNNAEYGEYV TGPEVITAAS KEAMKKALYR IQSGEYAKMF ILEGKTNYPS 300
    MTARRRLTAD HPIEKVGAEL RAMMPWIAKN KLVDQSKN 338
    Length:338
    Mass (Da):36,701
    Last modified:May 26, 2009 - v1
    Checksum:i1EA5FEDCE2B4AFFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001154 Genomic DNA. Translation: ACO73154.1.
    RefSeqiYP_002794163.1. NC_012559.1.

    Genome annotation databases

    EnsemblBacteriaiACO73154; ACO73154; LHK_00158.
    GeneIDi7755786.
    KEGGilhk:LHK_00158.
    PATRICi22297443. VBILarHon49832_0157.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001154 Genomic DNA. Translation: ACO73154.1 .
    RefSeqi YP_002794163.1. NC_012559.1.

    3D structure databases

    ProteinModelPortali C1DA41.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557598.LHK_00158.

    Proteomic databases

    PRIDEi C1DA41.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO73154 ; ACO73154 ; LHK_00158 .
    GeneIDi 7755786.
    KEGGi lhk:LHK_00158.
    PATRICi 22297443. VBILarHon49832_0157.

    Phylogenomic databases

    eggNOGi COG0059.
    HOGENOMi HOG000016230.
    KOi K00053.
    OMAi RFAKDFI.
    OrthoDBi EOG625K07.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .
    BioCyci LHON557598:GHO5-158-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
      Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
      PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HLHK9.

    Entry informationi

    Entry nameiILVC_LARHH
    AccessioniPrimary (citable) accession number: C1DA41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3