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C1DA02

- SYL_LARHH

UniProt

C1DA02 - SYL_LARHH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei633 – 6331ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLHON557598:GHO5-119-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LHK_00119
    OrganismiLaribacter hongkongensis (strain HLHK9)
    Taxonomic identifieri557598 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
    ProteomesiUP000002010: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 866866Leucine--tRNA ligasePRO_1000199211Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557598.LHK_00119.

    Structurei

    3D structure databases

    ProteinModelPortaliC1DA02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi630 – 6345"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1DA02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHEQYQPRDI EVAAQQKWEK TAAFKAVEDA SRPKYYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VLSRYMALKG YNVLQPMGWD AFGMPAENAA LKNQVAPAAW 100
    TYSNIEYMKT QLKSLGFAID WEREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
    RKNGVVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYFGITQYAD 200
    ELLADLDTLD WPPQVATMQR NWIGKSFGAD VRFAYDEASI GSAGELTVYT 250
    TRPDTLMGAT YVAVAAEHPL ATQAAANDPA LQAFIAKCKA GSVAEADMAT 300
    MEKEGMPTGL FVVHPLTGAK LPVWVANYVL MSYGSGAVMA VPAHDERDFA 350
    FANKYALPIQ QVIALKEGDA TFDASTWQDW YATKDDSTRL VNSGKYDGLD 400
    FQGAFDAIVA DLAAKAAGEK KTQYRLRDWG ISRQRYWGCP IPIIHCDSCG 450
    DVPVPADQLP VVLPENVVPD GSGNPLAKMP EFYETTCPCC GKPARRETDT 500
    MDTFVESSWY FARYASPDCA TGMVDDRARY WLNVDQYIGG IEHAILHLLY 550
    ARFFNKLMRD EGLLANDEPF QRLLTQGMVV CETFYRDLDN GSKEWITPAD 600
    VVIERDGKGK IIAATHKADG LPVVVGGIEK MSKSKNNGVD PQALIEQYGA 650
    DTARLFMMFA APPSQSLEWS DAGVEGAYRF LKRLYKIVSE YVAGGVAERF 700
    VAGELTADEK ALRLKLHTTI QKVSDDFGVR QQFNTAIAAV MELLNLFDRT 750
    EASRAVRQEV LESVVVLLSP IVPHICETLW SALKPGSELL AQRWPEVDPA 800
    ALVQDEIELV VQVNGKLRGS VRVAADAGRD VIEAAALAHE QVRKFMDGQP 850
    AKKVIVVPGR LVNIVV 866
    Length:866
    Mass (Da):96,345
    Last modified:May 26, 2009 - v1
    Checksum:i788FA95730AC2446
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001154 Genomic DNA. Translation: ACO73115.1.
    RefSeqiYP_002794124.1. NC_012559.1.

    Genome annotation databases

    EnsemblBacteriaiACO73115; ACO73115; LHK_00119.
    GeneIDi7755747.
    KEGGilhk:LHK_00119.
    PATRICi22297369. VBILarHon49832_0120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001154 Genomic DNA. Translation: ACO73115.1 .
    RefSeqi YP_002794124.1. NC_012559.1.

    3D structure databases

    ProteinModelPortali C1DA02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557598.LHK_00119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO73115 ; ACO73115 ; LHK_00119 .
    GeneIDi 7755747.
    KEGGi lhk:LHK_00119.
    PATRICi 22297369. VBILarHon49832_0120.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LHON557598:GHO5-119-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
      Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
      PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HLHK9.

    Entry informationi

    Entry nameiSYL_LARHH
    AccessioniPrimary (citable) accession number: C1DA02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3