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C1DA02

- SYL_LARHH

UniProt

C1DA02 - SYL_LARHH

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Protein

Leucine--tRNA ligase

Gene
leuS, LHK_00119
Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLHON557598:GHO5-119-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:LHK_00119
OrganismiLaribacter hongkongensis (strain HLHK9)
Taxonomic identifieri557598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
ProteomesiUP000002010: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 866866Leucine--tRNA ligaseUniRule annotationPRO_1000199211Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557598.LHK_00119.

Structurei

3D structure databases

ProteinModelPortaliC1DA02.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi630 – 6345"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DA02-1 [UniParc]FASTAAdd to Basket

« Hide

MHEQYQPRDI EVAAQQKWEK TAAFKAVEDA SRPKYYCLSM FPYPSGKLHM    50
GHVRNYTIGD VLSRYMALKG YNVLQPMGWD AFGMPAENAA LKNQVAPAAW 100
TYSNIEYMKT QLKSLGFAID WEREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
RKNGVVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYFGITQYAD 200
ELLADLDTLD WPPQVATMQR NWIGKSFGAD VRFAYDEASI GSAGELTVYT 250
TRPDTLMGAT YVAVAAEHPL ATQAAANDPA LQAFIAKCKA GSVAEADMAT 300
MEKEGMPTGL FVVHPLTGAK LPVWVANYVL MSYGSGAVMA VPAHDERDFA 350
FANKYALPIQ QVIALKEGDA TFDASTWQDW YATKDDSTRL VNSGKYDGLD 400
FQGAFDAIVA DLAAKAAGEK KTQYRLRDWG ISRQRYWGCP IPIIHCDSCG 450
DVPVPADQLP VVLPENVVPD GSGNPLAKMP EFYETTCPCC GKPARRETDT 500
MDTFVESSWY FARYASPDCA TGMVDDRARY WLNVDQYIGG IEHAILHLLY 550
ARFFNKLMRD EGLLANDEPF QRLLTQGMVV CETFYRDLDN GSKEWITPAD 600
VVIERDGKGK IIAATHKADG LPVVVGGIEK MSKSKNNGVD PQALIEQYGA 650
DTARLFMMFA APPSQSLEWS DAGVEGAYRF LKRLYKIVSE YVAGGVAERF 700
VAGELTADEK ALRLKLHTTI QKVSDDFGVR QQFNTAIAAV MELLNLFDRT 750
EASRAVRQEV LESVVVLLSP IVPHICETLW SALKPGSELL AQRWPEVDPA 800
ALVQDEIELV VQVNGKLRGS VRVAADAGRD VIEAAALAHE QVRKFMDGQP 850
AKKVIVVPGR LVNIVV 866
Length:866
Mass (Da):96,345
Last modified:May 26, 2009 - v1
Checksum:i788FA95730AC2446
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO73115.1.
RefSeqiYP_002794124.1. NC_012559.1.

Genome annotation databases

EnsemblBacteriaiACO73115; ACO73115; LHK_00119.
GeneIDi7755747.
KEGGilhk:LHK_00119.
PATRICi22297369. VBILarHon49832_0120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO73115.1 .
RefSeqi YP_002794124.1. NC_012559.1.

3D structure databases

ProteinModelPortali C1DA02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557598.LHK_00119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO73115 ; ACO73115 ; LHK_00119 .
GeneIDi 7755747.
KEGGi lhk:LHK_00119.
PATRICi 22297369. VBILarHon49832_0120.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LHON557598:GHO5-119-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
    Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
    PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLHK9.

Entry informationi

Entry nameiSYL_LARHH
AccessioniPrimary (citable) accession number: C1DA02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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