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C1DA02

- SYL_LARHH

UniProt

C1DA02 - SYL_LARHH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLHON557598:GHO5-119-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LHK_00119
OrganismiLaribacter hongkongensis (strain HLHK9)
Taxonomic identifieri557598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
ProteomesiUP000002010: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 866866Leucine--tRNA ligasePRO_1000199211Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557598.LHK_00119.

Structurei

3D structure databases

ProteinModelPortaliC1DA02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi630 – 6345"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1DA02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHEQYQPRDI EVAAQQKWEK TAAFKAVEDA SRPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRYMALKG YNVLQPMGWD AFGMPAENAA LKNQVAPAAW
110 120 130 140 150
TYSNIEYMKT QLKSLGFAID WEREVTTCKP DYYRWEQWLF TRLFEKGVIY
160 170 180 190 200
RKNGVVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYFGITQYAD
210 220 230 240 250
ELLADLDTLD WPPQVATMQR NWIGKSFGAD VRFAYDEASI GSAGELTVYT
260 270 280 290 300
TRPDTLMGAT YVAVAAEHPL ATQAAANDPA LQAFIAKCKA GSVAEADMAT
310 320 330 340 350
MEKEGMPTGL FVVHPLTGAK LPVWVANYVL MSYGSGAVMA VPAHDERDFA
360 370 380 390 400
FANKYALPIQ QVIALKEGDA TFDASTWQDW YATKDDSTRL VNSGKYDGLD
410 420 430 440 450
FQGAFDAIVA DLAAKAAGEK KTQYRLRDWG ISRQRYWGCP IPIIHCDSCG
460 470 480 490 500
DVPVPADQLP VVLPENVVPD GSGNPLAKMP EFYETTCPCC GKPARRETDT
510 520 530 540 550
MDTFVESSWY FARYASPDCA TGMVDDRARY WLNVDQYIGG IEHAILHLLY
560 570 580 590 600
ARFFNKLMRD EGLLANDEPF QRLLTQGMVV CETFYRDLDN GSKEWITPAD
610 620 630 640 650
VVIERDGKGK IIAATHKADG LPVVVGGIEK MSKSKNNGVD PQALIEQYGA
660 670 680 690 700
DTARLFMMFA APPSQSLEWS DAGVEGAYRF LKRLYKIVSE YVAGGVAERF
710 720 730 740 750
VAGELTADEK ALRLKLHTTI QKVSDDFGVR QQFNTAIAAV MELLNLFDRT
760 770 780 790 800
EASRAVRQEV LESVVVLLSP IVPHICETLW SALKPGSELL AQRWPEVDPA
810 820 830 840 850
ALVQDEIELV VQVNGKLRGS VRVAADAGRD VIEAAALAHE QVRKFMDGQP
860
AKKVIVVPGR LVNIVV
Length:866
Mass (Da):96,345
Last modified:May 26, 2009 - v1
Checksum:i788FA95730AC2446
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO73115.1.
RefSeqiYP_002794124.1. NC_012559.1.

Genome annotation databases

EnsemblBacteriaiACO73115; ACO73115; LHK_00119.
GeneIDi7755747.
KEGGilhk:LHK_00119.
PATRICi22297369. VBILarHon49832_0120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO73115.1 .
RefSeqi YP_002794124.1. NC_012559.1.

3D structure databases

ProteinModelPortali C1DA02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557598.LHK_00119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO73115 ; ACO73115 ; LHK_00119 .
GeneIDi 7755747.
KEGGi lhk:LHK_00119.
PATRICi 22297369. VBILarHon49832_0120.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LHON557598:GHO5-119-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
    Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
    PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLHK9.

Entry informationi

Entry nameiSYL_LARHH
AccessioniPrimary (citable) accession number: C1DA02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3