Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C1DA02 (SYL_LARHH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:LHK_00119
OrganismLaribacter hongkongensis (strain HLHK9) [Complete proteome] [HAMAP]
Taxonomic identifier557598 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeLaribacter

Protein attributes

Sequence length866 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 866866Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000199211

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif630 – 6345"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C1DA02 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 788FA95730AC2446

FASTA86696,345
        10         20         30         40         50         60 
MHEQYQPRDI EVAAQQKWEK TAAFKAVEDA SRPKYYCLSM FPYPSGKLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VLSRYMALKG YNVLQPMGWD AFGMPAENAA LKNQVAPAAW TYSNIEYMKT QLKSLGFAID 

       130        140        150        160        170        180 
WEREVTTCKP DYYRWEQWLF TRLFEKGVIY RKNGVVNWDP VDQTVLANEQ VIDGRGWRSG 

       190        200        210        220        230        240 
ALVEKREIPM YYFGITQYAD ELLADLDTLD WPPQVATMQR NWIGKSFGAD VRFAYDEASI 

       250        260        270        280        290        300 
GSAGELTVYT TRPDTLMGAT YVAVAAEHPL ATQAAANDPA LQAFIAKCKA GSVAEADMAT 

       310        320        330        340        350        360 
MEKEGMPTGL FVVHPLTGAK LPVWVANYVL MSYGSGAVMA VPAHDERDFA FANKYALPIQ 

       370        380        390        400        410        420 
QVIALKEGDA TFDASTWQDW YATKDDSTRL VNSGKYDGLD FQGAFDAIVA DLAAKAAGEK 

       430        440        450        460        470        480 
KTQYRLRDWG ISRQRYWGCP IPIIHCDSCG DVPVPADQLP VVLPENVVPD GSGNPLAKMP 

       490        500        510        520        530        540 
EFYETTCPCC GKPARRETDT MDTFVESSWY FARYASPDCA TGMVDDRARY WLNVDQYIGG 

       550        560        570        580        590        600 
IEHAILHLLY ARFFNKLMRD EGLLANDEPF QRLLTQGMVV CETFYRDLDN GSKEWITPAD 

       610        620        630        640        650        660 
VVIERDGKGK IIAATHKADG LPVVVGGIEK MSKSKNNGVD PQALIEQYGA DTARLFMMFA 

       670        680        690        700        710        720 
APPSQSLEWS DAGVEGAYRF LKRLYKIVSE YVAGGVAERF VAGELTADEK ALRLKLHTTI 

       730        740        750        760        770        780 
QKVSDDFGVR QQFNTAIAAV MELLNLFDRT EASRAVRQEV LESVVVLLSP IVPHICETLW 

       790        800        810        820        830        840 
SALKPGSELL AQRWPEVDPA ALVQDEIELV VQVNGKLRGS VRVAADAGRD VIEAAALAHE 

       850        860 
QVRKFMDGQP AKKVIVVPGR LVNIVV 

« Hide

References

[1]"The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HLHK9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001154 Genomic DNA. Translation: ACO73115.1.
RefSeqYP_002794124.1. NC_012559.1.

3D structure databases

ProteinModelPortalC1DA02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING557598.LHK_00119.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO73115; ACO73115; LHK_00119.
GeneID7755747.
KEGGlhk:LHK_00119.
PATRIC22297369. VBILarHon49832_0120.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycLHON557598:GHO5-119-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_LARHH
AccessionPrimary (citable) accession number: C1DA02
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries