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C1D9G3

- NAPA_LARHH

UniProt

C1D9G3 - NAPA_LARHH

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Protein

Periplasmic nitrate reductase

Gene
napA, LHK_02081
Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism By similarity.UniRule annotation

Catalytic activityi

Nitrite + acceptor = nitrate + reduced acceptor.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster By similarity.UniRule annotation
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Iron-sulfur (4Fe-4S) By similarity
Metal bindingi56 – 561Iron-sulfur (4Fe-4S) By similarity
Metal bindingi60 – 601Iron-sulfur (4Fe-4S) By similarity
Metal bindingi88 – 881Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. electron carrier activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. molybdenum ion binding Source: InterPro
  5. nitrate reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
  2. nitrate assimilation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Nitrate assimilation, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciLHON557598:GHO5-2111-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic nitrate reductase (EC:1.7.99.4)
Gene namesi
Name:napA
Ordered Locus Names:LHK_02081
OrganismiLaribacter hongkongensis (strain HLHK9)
Taxonomic identifieri557598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
ProteomesiUP000002010: Chromosome

Subcellular locationi

Periplasm By similarity UniRule annotation

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Tat-type signal Reviewed predictionAdd
BLAST
Chaini35 – 839805Periplasmic nitrate reductaseUniRule annotationPRO_1000186366Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.UniRule annotation

Interactioni

Subunit structurei

Interacts with NapB By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi557598.LHK_02081.

Structurei

3D structure databases

ProteinModelPortaliC1D9G3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 102574Fe-4S Mo/W bis-MGD-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0243.
HOGENOMiHOG000031441.
KOiK02567.
OMAiCACKVER.
OrthoDBiEOG6CVV7G.

Family and domain databases

HAMAPiMF_01630. Nitrate_reduct.
InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01706. NAPA. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1D9G3-1 [UniParc]FASTAAdd to Basket

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MTLTRRDFIK ANAAAAAATA AAVNLPLVPS MAQAATTDPA TAGADIKWDK    50
AACRFCGTGC SVLVGTKGGR VVATQGDPDA PVNRGLNCIK GYFLSKIMYG 100
EDRLTKPLLR MKNGKFDKNG EFTPVTWKQA FDVMEEKFKT AMKAGGPEAV 150
AMFGSGQWTI WEGYAAAKFM KAGLRSNNLD PNARHCMASA VVGFMRTFNM 200
DEPMGCYDDI EKADAFVLWG SNMAEMHPIL WSRITDRRLT HPDCQVHVLS 250
TYEHRSFELA DNKLVFGPQT DLAILNYIAN HIIQTGAVNK DFIQKYCAFM 300
KGDTDIGYGL RPTHPKQKAA KNPDSGKMDP ITFEQFAAFV KPYTLEYTAR 350
TSCVPAERLK RLAELYADPK KKVVSFWTMG FNQHTRGTWA NNLVYNIHLL 400
TGKISTPGCG PFSLTGQPSA CGTAREVGTF AHRLPADLVV MNPEHRKIAE 450
NIWKLPEGTI PPKMGLHAVA MQRALKDSKL KVYWQQCNNN MQAGPNINEE 500
MYPGWRNPET FIIVSDPYPT VSAMAADLIL PTAMWVEKEG AYGNAERRTQ 550
FWRQQVNAPG EAKSDLWQVV EFSKRFKVEE VWPAELVAKK PEYRGKTLYD 600
VLFANGQVNK YKLDDMARQH GTAYHNEEAR HVGFYLQKGL FEEYAAFGRG 650
HGHDLALFDT YHKARGLRWP VVDGKETLWR YREGFDPYVK KGEGVRFYGQ 700
KDGRARIIAL PFEPAAEVPD REYNMWLCTG RVLEHWHTGS MTRRVPELYR 750
AVPDAQVFMH PADAELRGLK RGQQVKVISR RGEITLTLET RGRNKPPQGL 800
VFIPFFDEGR LVNKLTLDAT CPLSKETDYK KCAVKVVRA 839
Length:839
Mass (Da):94,304
Last modified:May 26, 2009 - v1
Checksum:i1C02424A6F70B510
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO75065.1.
RefSeqiYP_002796074.1. NC_012559.1.

Genome annotation databases

EnsemblBacteriaiACO75065; ACO75065; LHK_02081.
GeneIDi7757694.
KEGGilhk:LHK_02081.
PATRICi22301017. VBILarHon49832_1897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO75065.1 .
RefSeqi YP_002796074.1. NC_012559.1.

3D structure databases

ProteinModelPortali C1D9G3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557598.LHK_02081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO75065 ; ACO75065 ; LHK_02081 .
GeneIDi 7757694.
KEGGi lhk:LHK_02081.
PATRICi 22301017. VBILarHon49832_1897.

Phylogenomic databases

eggNOGi COG0243.
HOGENOMi HOG000031441.
KOi K02567.
OMAi CACKVER.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci LHON557598:GHO5-2111-MONOMER.

Family and domain databases

HAMAPi MF_01630. Nitrate_reduct.
InterProi IPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view ]
Pfami PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view ]
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR01706. NAPA. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
    Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
    PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLHK9.

Entry informationi

Entry nameiNAPA_LARHH
AccessioniPrimary (citable) accession number: C1D9G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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