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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi487MagnesiumUniRule annotation1
Metal bindingi493MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:LHK_01924
OrganismiLaribacter hongkongensis (strain HLHK9)
Taxonomic identifieri557598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
Proteomesi
  • UP000002010 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001857401 – 701Polyribonucleotide nucleotidyltransferaseAdd BLAST701

Interactioni

Protein-protein interaction databases

STRINGi557598.LHK_01924.

Structurei

3D structure databases

ProteinModelPortaliC1D8W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini553 – 612KHUniRule annotationAdd BLAST60
Domaini622 – 692S1 motifUniRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1D8W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNKFSKTFQ YGRHTVKLET GEIARQASGS VLVSMDDTVV LVAVTVNKDV
60 70 80 90 100
KPGQDFFPLT VDYYERTYAA GKIPGGFFKR EGKQSEKEIL TCRLIDRPIR
110 120 130 140 150
PLFPAGFYHD VQVVATVMSL NPEVDADIPA MIGASAAMVL AGVPFMGPIG
160 170 180 190 200
AARVGYANGE YILNPTKTEL TTSQLDLVVA GTESAVLMVE SEAQQLPEAV
210 220 230 240 250
MLGAVVYGHE QMQAAIKAIN ELADEVNPVI FEWAPAAEDT ELVAQVKALA
260 270 280 290 300
EADVAAAFKI RQKQARSQAL GEAWSKVKAA LITEETETLR ANHIKSLFKE
310 320 330 340 350
LEANVVRGQI LAGEPRIDGR DTRTVRPIAI RTGVLPRAHG SVLFTRGETQ
360 370 380 390 400
ALVSTTLGTK QDEQIIDALA GEYTDRFMLH YNFPPYSTGE TGRMGPPKRR
410 420 430 440 450
EIGHGRLAKR ALIAVLPKQE DFSYSMRVVS EITESNGSSS MASVCGGCLS
460 470 480 490 500
LMNAGVPLSA HVAGIAMGLI LEDNRFAVLT DILGDEDHLG DMDFKVAGTE
510 520 530 540 550
NGVTALQMDI KIQGITKEIM QVALDQAKEG RLHILGIMKS AIDAPQELST
560 570 580 590 600
HAPRLYTLRI NPDKIRDVIG KGGSVIRALT EETGTSIDIA EDGLITIASV
610 620 630 640 650
SAEGAEEAKR RIEEITAEVE IGKIYEGTVV KILDKNVGAI VQIMPGRDGL
660 670 680 690 700
VHISQIANER IANVADHLQE GQQVRVKVLE TDERGRIRLS IKAALADAPQ

V
Length:701
Mass (Da):75,867
Last modified:May 26, 2009 - v1
Checksum:i997133F4BDC6C248
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001154 Genomic DNA. Translation: ACO74908.1.
RefSeqiWP_012697394.1. NC_012559.1.

Genome annotation databases

EnsemblBacteriaiACO74908; ACO74908; LHK_01924.
KEGGilhk:LHK_01924.
PATRICi22300733. VBILarHon49832_1759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001154 Genomic DNA. Translation: ACO74908.1.
RefSeqiWP_012697394.1. NC_012559.1.

3D structure databases

ProteinModelPortaliC1D8W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi557598.LHK_01924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO74908; ACO74908; LHK_01924.
KEGGilhk:LHK_01924.
PATRICi22300733. VBILarHon49832_1759.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_LARHH
AccessioniPrimary (citable) accession number: C1D8W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.