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C1D6F1

- PUR9_LARHH

UniProt

C1D6F1 - PUR9_LARHH

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, LHK_03208
Organism
Laribacter hongkongensis (strain HLHK9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLHON557598:GHO5-3272-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:LHK_03208
OrganismiLaribacter hongkongensis (strain HLHK9)
Taxonomic identifieri557598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeLaribacter
ProteomesiUP000002010: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000122962Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557598.LHK_03208.

Structurei

3D structure databases

ProteinModelPortaliC1D6F1.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C1D6F1-1 [UniParc]FASTAAdd to Basket

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MTKIERALIS VSDKTGILEF ARGLAAHGVE ILSTGGTAKL LADNNVPVIE    50
VADYTGFPEM LDGRVKTLHP KIHGGILGRR DLPEHVAKMA EHGIGNIDLV 100
CVNLYPFEAT IAKEGCALED AIENIDIGGP TMVRSAAKNW AHVAIVTDAA 150
DYPALLEEMG ANAGALSRAT RFDLSRKAFT HTAAYDGAIS NYLTAVQADQ 200
GLAGEPVRTL FPTRLNLQVV KVQDMRYGEN PHQSAAFYRD LDPAPGTLAH 250
YRQLQGKELS YNNIADSDAA WEAVKTFDDP ACVIVKHANP CGVAVAADPL 300
SAYRLAFATD TTSAFGGIIA FNREVDAATV EAVSAQFLEV LIAPAFTDDA 350
KALIAAKKNV RVLEVPVEAG ANRFELKRVG GGLLVQTPDI KNVTLDELKV 400
VTKAQPTRQQ LADLLFAWRV AKFVKSNAIV FAAGGQTAGI GAGQMSRVDS 450
TRIAARKAQD AGLSLKNAVA ASDAFFPFRD GVDVIAEQGI SAIIQPGGSM 500
RDEEVIKAAD EHGIAMVFTG NRHFRH 526
Length:526
Mass (Da):56,135
Last modified:May 26, 2009 - v1
Checksum:i82364408DBB769E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO76186.1.
RefSeqiWP_012698649.1. NC_012559.1.
YP_002797195.1. NC_012559.1.

Genome annotation databases

EnsemblBacteriaiACO76186; ACO76186; LHK_03208.
GeneIDi7758815.
KEGGilhk:LHK_03208.
PATRICi22303172. VBILarHon49832_2936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001154 Genomic DNA. Translation: ACO76186.1 .
RefSeqi WP_012698649.1. NC_012559.1.
YP_002797195.1. NC_012559.1.

3D structure databases

ProteinModelPortali C1D6F1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557598.LHK_03208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO76186 ; ACO76186 ; LHK_03208 .
GeneIDi 7758815.
KEGGi lhk:LHK_03208.
PATRICi 22303172. VBILarHon49832_2936.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LHON557598:GHO5-3272-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats."
    Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y.
    PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLHK9.

Entry informationi

Entry nameiPUR9_LARHH
AccessioniPrimary (citable) accession number: C1D6F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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