C1D5W4 (SYR_LARHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	LHK_01003

Organism

Laribacter hongkongensis (strain HLHK9) [Complete proteome] [HAMAP]

Taxonomic identifier

557598 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Laribacter › Laribacter hongkongensis

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 573	573	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_1000198912
Regions
	Motif	122 – 132	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	C1D5W4 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 963EDDE0EF099AD2	FASTA	573	63,639
	10 20 30 40 50 60 MTLTQLLHDK LAAALIAAGV PDAQPLLQPA SRPEFGDFQA NGVMAAAKQR KMNPRELAQQ 70 80 90 100 110 120 VIDKLDLAGI ASKIEIAGPG FINITLAPDF LAKRLDTVLD DARLGVRSVT EPQRVMVEYS 130 140 150 160 170 180 SPNLAKEMHV GHLRSTIIGD TLARVVEFLG NNMVRGNHVG DWGTQFGMLT AYLVETRQAG 190 200 210 220 230 240 KADLELSDLE TFYRNAKIRF DEDPVFADTA RNYVVRLQGG DADVLKLWEQ FVDVSLAHCE 250 260 270 280 290 300 AVYRKLGVGL TRADVRGESA YNDDLPVIVD ELAAKNLLSE DDGAKVVYLD EFRNHDGDPM 310 320 330 340 350 360 GVIVQKKDGG FLYTTTDLGA VRYRHKELNL DRVIYVVDAR QSQHFQQMFT ICRKAGFAPE 370 380 390 400 410 420 AMSLEHVGFG TMMGDDGKPF KTRSGGTVKL IELLDEAEER AYALVSEKNP DLPEEEKRKI 430 440 450 460 470 480 AHAVGIGAVK YADLSKNRNS DYIFNWDLML AFEGNTAPYL QYAYTRVASI FRKVDRFDAS 490 500 510 520 530 540 APLLITEPAE KQLALMLAQF SDVLNEVART CFPHLLTQYL YQVATQFMRF YEACPILKSE 550 560 570 GATQASRLKL ARITADTLKT GLGLLGIEVL ESM

References

[1]

"The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats." Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y. PLoS Genet. 5:E1000416-E1000416(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HLHK9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001154 Genomic DNA. Translation: ACO73995.1.
RefSeq	YP_002795004.1. NC_012559.1.
3D structure databases
ProteinModelPortal	C1D5W4.
ModBase	Search...
Protein-protein interaction databases
STRING	557598.LHK_01003.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACO73995; ACO73995; LHK_01003.
GeneID	7756625.
KEGG	lhk:LHK_01003.
PATRIC	22299089. VBILarHon49832_0946.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247212.
KO	K01887.
OMA	QGAKCVF.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	LHON557598:GHO5-997-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_LARHH

Accession

Primary (citable) accession number: C1D5W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program