C1D5B2 (ARGC_LARHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	LHK_00937

Organism

Laribacter hongkongensis (strain HLHK9) [Complete proteome] [HAMAP]

Taxonomic identifier

557598 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Laribacter

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000123243
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1D5B2 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 48BBE5E7BC6B5239	FASTA	342	36,590
	10 20 30 40 50 60 MIKVGIVGGT GYTGVELLRL LSRHPDVELT AITSRKEAGL RVDAMYPSLR GWVDLAFTTP 70 80 90 100 110 120 DEANLAGCDV VFFATPNGIA MQEAVRLVEA GVRVIDLAAD FRIKDIAEWE KWYGMTHASP 130 140 150 160 170 180 QLVAEAVYGL PEINRDAVRT ARVVANPGCY PTAVQLGFLP LIEAEAIDPA SLIADCKSGV 190 200 210 220 230 240 SGAGRKAEVH TLFAEATDSF KAYGVAGHRH LPEIRQGLAA VAGQPVGLTF VPHLTPMVRG 250 260 270 280 290 300 IHATLYARLK KDVDLQGLFE SRYAGERFVD VLPAGSCPET RSVRGSNTCR IAVHRPQGSD 310 320 330 340 TVVVLSVIDN LVKGAAGQAV QNLNLMFGLP ESTGLEIVPL MP

References

[1]

"The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats." Woo P.C.Y., Lau S.K.P., Tse H., Teng J.L.L., Curreem S.O., Tsang A.K.L., Fan R.Y.Y., Wong G.K.M., Huang Y., Loman N.J., Snyder L.A.S., Cai J.J., Huang J.-D., Mak W., Pallen M.J., Lok S., Yuen K.-Y. PLoS Genet. 5:E1000416-E1000416(2009) [PubMed: 19283063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HLHK9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001154 Genomic DNA. Translation: ACO73929.1.
RefSeq	YP_002794938.1. NC_012559.1.
3D structure databases
ProteinModelPortal	C1D5B2.
ModBase	Search...
Protein-protein interaction databases
STRING	C1D5B2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7756559.
GenomeReviews	Gene locus LHK_00937 in contig CP001154_GR.
KEGG	lhk:LHK_00937.
PATRIC	22298961. VBILarHon49832_0882.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TAEDCTT.
ProtClustDB	PRK00436.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_LARHH

Accession

Primary (citable) accession number: C1D5B2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program