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C1D325

- C1D325_DEIDV

UniProt

C1D325 - C1D325_DEIDV

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Protein

Kynureninase

Gene
kynU, Deide_2p01450
Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei111 – 1111Pyridoxal phosphate By similarityUniRule annotation
Binding sitei181 – 1811Pyridoxal phosphate By similarityUniRule annotation
Binding sitei210 – 2101Pyridoxal phosphate By similarityUniRule annotation
Binding sitei213 – 2131Pyridoxal phosphate By similarityUniRule annotation
Binding sitei235 – 2351Pyridoxal phosphate By similarityUniRule annotation
Binding sitei264 – 2641Pyridoxal phosphate By similarityUniRule annotation
Binding sitei290 – 2901Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciDDES546414:GHOM-3432-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Deide_2p01450Imported
Encoded oniPlasmid pDeide2
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)Imported
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002208: Plasmid pDeide2

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Proteomic databases

PaxDbiC1D325.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi546414.Deide_2p01450.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1424Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiYACESHI.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C1D325-1 [UniParc]FASTAAdd to Basket

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MTTPVLSAKP ALSTLLDLDA RDPLQHKKAQ FVLPEGVIYL DGNSLGALPA    50
TVPARLERVI HQEWGDALIR SWTAHAQEGR DWMALPDRVA AKLAPLIGAE 100
ASEISVGDST SVNLFKALTA ALDVASPGRR VILTDADNFP TDLYVAQGLN 150
GLLDGRYELR RVPAAELSAH LTTDVAAMMV TEVDYRTGER LDMASLTAQA 200
HAQGIVTIWD LAHSAGAFEV DLTAARADFA VGCGYKYLNG GPGAPGYLFV 250
ASRHLQARVA LSGWMGHADP FEMARDYTPA KDARRFIVGT PTVLSLSALD 300
TALDVFADVD LKQLRAKSLA LTDTFMALVA GDPDLTLVTP LDHARRGSQV 350
SFRHPQAREA MRRLVERGVI GDFRTPDILR FGFTPLYVSY ADVYRAAQAV 400
LDVAGELRA 409
Length:409
Mass (Da):44,171
Last modified:May 26, 2009 - v1
Checksum:i4DFE06C0F2B2F327
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001116 Genomic DNA. Translation: ACO47814.1.
RefSeqiYP_002787916.1. NC_012529.1.

Genome annotation databases

EnsemblBacteriaiACO47814; ACO47814; Deide_2p01450.
GeneIDi7740681.
KEGGiddr:Deide_2p01450.
PATRICi21620493. VBIDeiDes121019_3511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001116 Genomic DNA. Translation: ACO47814.1 .
RefSeqi YP_002787916.1. NC_012529.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546414.Deide_2p01450.

Proteomic databases

PaxDbi C1D325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO47814 ; ACO47814 ; Deide_2p01450 .
GeneIDi 7740681.
KEGGi ddr:Deide_2p01450.
PATRICi 21620493. VBIDeiDes121019_3511.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242437.
KOi K01556.
OMAi YACESHI.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci DDES546414:GHOM-3432-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Plasmid pDeide2 and VCD115 / DSM 17065 / LMG 22923.

Entry informationi

Entry nameiC1D325_DEIDV
AccessioniPrimary (citable) accession number: C1D325
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported

External Data

Dasty 3

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