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C1D325

- C1D325_DEIDV

UniProt

C1D325 - C1D325_DEIDV

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Protein

Kynureninase

Gene

kynU

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei111 – 1111Pyridoxal phosphateUniRule annotation
Binding sitei181 – 1811Pyridoxal phosphateUniRule annotation
Binding sitei210 – 2101Pyridoxal phosphateUniRule annotation
Binding sitei213 – 2131Pyridoxal phosphateUniRule annotation
Binding sitei235 – 2351Pyridoxal phosphateUniRule annotation
Binding sitei264 – 2641Pyridoxal phosphateUniRule annotation
Binding sitei290 – 2901Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciDDES546414:GHOM-3432-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Deide_2p01450Imported
Encoded oniPlasmid pDeide2Imported
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)Imported
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002208: Plasmid pDeide2

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiC1D325.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi546414.Deide_2p01450.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1424Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiYACESHI.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C1D325-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPVLSAKP ALSTLLDLDA RDPLQHKKAQ FVLPEGVIYL DGNSLGALPA
60 70 80 90 100
TVPARLERVI HQEWGDALIR SWTAHAQEGR DWMALPDRVA AKLAPLIGAE
110 120 130 140 150
ASEISVGDST SVNLFKALTA ALDVASPGRR VILTDADNFP TDLYVAQGLN
160 170 180 190 200
GLLDGRYELR RVPAAELSAH LTTDVAAMMV TEVDYRTGER LDMASLTAQA
210 220 230 240 250
HAQGIVTIWD LAHSAGAFEV DLTAARADFA VGCGYKYLNG GPGAPGYLFV
260 270 280 290 300
ASRHLQARVA LSGWMGHADP FEMARDYTPA KDARRFIVGT PTVLSLSALD
310 320 330 340 350
TALDVFADVD LKQLRAKSLA LTDTFMALVA GDPDLTLVTP LDHARRGSQV
360 370 380 390 400
SFRHPQAREA MRRLVERGVI GDFRTPDILR FGFTPLYVSY ADVYRAAQAV

LDVAGELRA
Length:409
Mass (Da):44,171
Last modified:May 26, 2009 - v1
Checksum:i4DFE06C0F2B2F327
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001116 Genomic DNA. Translation: ACO47814.1.
RefSeqiWP_012695284.1. NC_012529.1.
YP_002787916.1. NC_012529.1.

Genome annotation databases

EnsemblBacteriaiACO47814; ACO47814; Deide_2p01450.
GeneIDi7740681.
KEGGiddr:Deide_2p01450.
PATRICi21620493. VBIDeiDes121019_3511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001116 Genomic DNA. Translation: ACO47814.1 .
RefSeqi WP_012695284.1. NC_012529.1.
YP_002787916.1. NC_012529.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546414.Deide_2p01450.

Proteomic databases

PaxDbi C1D325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO47814 ; ACO47814 ; Deide_2p01450 .
GeneIDi 7740681.
KEGGi ddr:Deide_2p01450.
PATRICi 21620493. VBIDeiDes121019_3511.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242437.
KOi K01556.
OMAi YACESHI.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci DDES546414:GHOM-3432-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiC1D325_DEIDV
AccessioniPrimary (citable) accession number: C1D325
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported, Reference proteomeImported

External Data

Dasty 3