C1D141 (ARGC_DEIDV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Deide_07080

Organism

Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923) [Complete proteome] [HAMAP]

Taxonomic identifier

546414 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm By similarity HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000213574
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1D141 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 456BBE5AF3270608	FASTA	308	32,657
	10 20 30 40 50 60 MTRPRVFIDG EAGTTGLQIR ARLSGRTDLE LLSIDPARRK DPQARAELLN AANVSILCLH 70 80 90 100 110 120 DDAAREAVAL TTNPEARLLD ASTAHRVHPE WVFGFPELSA QQPDRIRAAR YVANPGCYST 130 140 150 160 170 180 GAIALLAPLT AAGLLSADFP VSIQGYSGYT GGGRALVDAH EKGEAHPMRG PFLSYALGLG 190 200 210 220 230 240 HKHIPETMRY GGLSRTPIFT PNVGAWAQGM TVTIPLHLSD LGVSAQALHG ALTAHYAGQK 250 260 270 280 290 300 YVRVAAMESN PEILDPQTLN GTNDLDLFVY ASQDGERAVL AARLDNLGKG AGGAAVQNLN LMLGLPDA

References

[1]

"Alliance of proteomics and genomics to unravel the specificities of Sahara bacterium Deinococcus deserti." de Groot A., Dulermo R., Ortet P., Blanchard L., Guerin P., Fernandez B., Vacherie B., Dossat C., Jolivet E., Siguier P., Chandler M., Barakat M., Dedieu A., Barbe V., Heulin T., Sommer S., Achouak W., Armengaud J. PLoS Genet. 5:E1000434-E1000434(2009) [PubMed: 19370165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCD115 / DSM 17065 / LMG 22923.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001114 Genomic DNA. Translation: ACO45565.1.
RefSeq	YP_002785319.1. NC_012526.1.
3D structure databases
ProteinModelPortal	C1D141.
ModBase	Search...
Protein-protein interaction databases
STRING	C1D141.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7738108.
GenomeReviews	Gene locus Deide_07080 in contig CP001114_GR.
KEGG	ddr:Deide_07080.
PATRIC	21615030. VBIDeiDes121019_0800.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PIFVPSV.
ProtClustDB	PRK11863.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR023013. AGPR_AS. IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_DEIDV

Accession

Primary (citable) accession number: C1D141

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program