C1D0Z6 (KITH_DEIDV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	Deide_06660

Organism

Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923) [Complete proteome] [HAMAP]

Taxonomic identifier

546414 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124
Subunit structure	Homotetramer By similarity. HAMAP MF_00124
Subcellular location	Cytoplasm Potential HAMAP MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Thymidine kinase HAMAP MF_00124		PRO_1000203110
Regions
	Nucleotide binding	16 – 23	8	ATP By similarity
	Nucleotide binding	99 – 102	4	ATP By similarity
Sites
	Active site	100	1	Proton acceptor Potential
	Metal binding	156	1	Zinc By similarity
	Metal binding	159	1	Zinc By similarity
	Metal binding	194	1	Zinc By similarity
	Metal binding	197	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1D0Z6 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: EE884E842CB25251	FASTA	202	21,720
	10 20 30 40 50 60 MLKSPYSGGH LEVIVGPMFS GKSEELIRRV TRALIARQRV QVFKPAVDDR YHESAVASHA 70 80 90 100 110 120 GRTVGALAVG DVADIRAHLS GEAPLLQASA EMPDVIGIDE VQFFGPELVP LALELADAGV 130 140 150 160 170 180 RVILAGLDLD FRAEPFGCMP DLLARAESVE KLTAICTQCG APATRSQRLI SGEPARFDDP 190 200 VVLVGALESY EARCRLHHVV TR

References

[1]

"Alliance of proteomics and genomics to unravel the specificities of Sahara bacterium Deinococcus deserti." de Groot A., Dulermo R., Ortet P., Blanchard L., Guerin P., Fernandez B., Vacherie B., Dossat C., Jolivet E., Siguier P., Chandler M., Barakat M., Dedieu A., Barbe V., Heulin T., Sommer S., Achouak W., Armengaud J. PLoS Genet. 5:E1000434-E1000434(2009) [PubMed: 19370165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCD115 / DSM 17065 / LMG 22923.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001114 Genomic DNA. Translation: ACO45520.1.
RefSeq	YP_002785274.1. NC_012526.1.
3D structure databases
ProteinModelPortal	C1D0Z6.
ModBase	Search...
Protein-protein interaction databases
STRING	C1D0Z6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7739320.
GenomeReviews	Gene locus Deide_06660 in contig CP001114_GR.
KEGG	ddr:Deide_06660.
PATRIC	21614938. VBIDeiDes121019_0754.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EPRCRHH.
ProtClustDB	PRK04296.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_DEIDV

Accession

Primary (citable) accession number: C1D0Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program