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Protein

Ribonuclease PH

Gene

rph

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.SAAS annotation

Catalytic activityi

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseImported, Hydrolase, Nuclease, NucleotidyltransferaseSAAS annotation, RNA-binding, Transferase, tRNA-bindingSAAS annotation
Biological processrRNA processingSAAS annotation, tRNA processingSAAS annotation

Enzyme and pathway databases

BioCyciDDES546414:G1GCG-2537-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease PHSAAS annotation (EC:2.7.7.56SAAS annotation)
Gene namesi
Name:rphImported
Ordered Locus Names:Deide_22100Imported
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)Imported
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002208 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiC1CZJ0

Interactioni

Subunit structurei

Homohexameric ring arranged as a trimer of dimers.SAAS annotation

Protein-protein interaction databases

STRINGi546414.Deide_22100

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 147RNase_PHInterPro annotationAdd BLAST128
Domaini166 – 229RNase_PH_CInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the RNase PH family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105ED0 Bacteria
COG0689 LUCA
HOGENOMiHOG000229516
KOiK00989
OMAiKGKGQGW
OrthoDBiPOG091H03ML

Family and domain databases

Gene3Di3.30.230.70, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR002381 RNase_PH_bac-type
IPR018336 RNase_PH_CS
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
PF03725 RNase_PH_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit
TIGRFAMsiTIGR01966 RNasePH, 1 hit
PROSITEiView protein in PROSITE
PS01277 RIBONUCLEASE_PH, 1 hit

Sequencei

Sequence statusi: Complete.

C1CZJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVQPNKFP PREGRGLLEP RPVSVKRGVN PHAPGSAHLI MGRTEILATV
60 70 80 90 100
TLEDKPAPHM RGKKEGWLTA EYSMLPRATN DRQARERNLQ NGRRHEIQRL
110 120 130 140 150
LGRALRASVD LKYFRNQTIY VDCDVLVADG GTRVASILAG HAALHDFCDR
160 170 180 190 200
LINSGQLSEW PLTHKVGAIS VGLVGEEVRV DLDYAEDKVA RADLNVVATD
210 220 230 240
TGLVIEVQGG AEEGPISLAE YSQLLHTGVQ AIHGVMDELG RELAVIQGV
Length:249
Mass (Da):27,199
Last modified:May 26, 2009 - v1
Checksum:i973B2E5D06DF694E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001114 Genomic DNA Translation: ACO47238.1
RefSeqiWP_012694359.1, NC_012526.1

Genome annotation databases

EnsemblBacteriaiACO47238; ACO47238; Deide_22100
KEGGiddr:Deide_22100

Similar proteinsi

Entry informationi

Entry nameiC1CZJ0_DEIDV
AccessioniPrimary (citable) accession number: C1CZJ0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health