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C1CY73

- MDH_DEIDV

UniProt

C1CY73 - MDH_DEIDV

Protein

Malate dehydrogenase

Gene

mdh

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation
    Binding sitei107 – 1071NADUniRule annotation
    Binding sitei114 – 1141NADUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Active sitei189 – 1891Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 197NADUniRule annotation
    Nucleotide bindingi131 – 1333NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciDDES546414:GHOM-2289-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Deide_20240
    OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
    Taxonomic identifieri546414 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002208: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Malate dehydrogenasePRO_1000215355Add
    BLAST

    Proteomic databases

    PaxDbiC1CY73.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi546414.Deide_20240.

    Structurei

    3D structure databases

    ProteinModelPortaliC1CY73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiWLENIMI.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1CY73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNKQPVRVA VTGAAGQIGY SLLFRIAAGD MLGKDQPVIL QLLEITPALK    50
    ALQGVVMELR DGAYPLLADV VTSDDPLVAF KDADYALLVG AMPRKAGMER 100
    GDLLGANGGI FKPQGQALNQ VASRDVKVLV VGNPANTNAL IAQQNAPDLD 150
    PRQFTAMVRL DHNRAISQLA EKTGQPVSAI KNITIWGNHS STQYPDLSQA 200
    TVGGRPALDL VDRTWYEQEY IPTVAKRGAA IIEARGASSA ASAASAAIDH 250
    MRDWALGTSE GEWVSMGIPS DGSYGVPEGL IYGFPVTVKD GKYQIVQGLE 300
    ISEFSRGKMD ATARELEEER DEIRKLGLIS 330
    Length:330
    Mass (Da):35,298
    Last modified:May 26, 2009 - v1
    Checksum:iD082DAEA0E614880
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001114 Genomic DNA. Translation: ACO47029.1.
    RefSeqiWP_012694150.1. NC_012526.1.
    YP_002786783.1. NC_012526.1.

    Genome annotation databases

    EnsemblBacteriaiACO47029; ACO47029; Deide_20240.
    GeneIDi7737744.
    KEGGiddr:Deide_20240.
    PATRICi21618096. VBIDeiDes121019_2321.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001114 Genomic DNA. Translation: ACO47029.1 .
    RefSeqi WP_012694150.1. NC_012526.1.
    YP_002786783.1. NC_012526.1.

    3D structure databases

    ProteinModelPortali C1CY73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 546414.Deide_20240.

    Proteomic databases

    PaxDbi C1CY73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO47029 ; ACO47029 ; Deide_20240 .
    GeneIDi 7737744.
    KEGGi ddr:Deide_20240.
    PATRICi 21618096. VBIDeiDes121019_2321.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi WLENIMI.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci DDES546414:GHOM-2289-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VCD115 / DSM 17065 / LMG 22923.

    Entry informationi

    Entry nameiMDH_DEIDV
    AccessioniPrimary (citable) accession number: C1CY73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3