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C1CXS7 (UNG_DEIDV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uracil-DNA glycosylase
Short name=UDG
EC=3.2.2.27
Gene names
Name:ung
Ordered Locus Names:Deide_00830
OrganismDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923) [Complete proteome] [HAMAP]
Taxonomic identifier546414 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus ›

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity. HAMAP-Rule MF_00148

Catalytic activity

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. HAMAP-Rule MF_00148

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processbase-excision repair

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuracil DNA N-glycosylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Uracil-DNA glycosylase HAMAP-Rule MF_00148
PRO_1000203373

Sites

Active site851Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
C1CXS7 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 1FA240D679FC43CB

FASTA24827,279
        10         20         30         40         50         60 
MSDQPDLFGT PTGAKAPHAI MPAGLPASWK EALAEEFAAP YFHALKDFLV EERRTHTVYP 

        70         80         90        100        110        120 
PAADVFNALR YTPLENVKVM ILGQDPYHGP GQAHGLSFSV RPGVRIPPSL KNIYKELQSD 

       130        140        150        160        170        180 
IPGFTPPRHG YLKAWAEQGV LLLNAVLTVR AGEANSHAGK GWESFTDAVI RAVNNRPQRV 

       190        200        210        220        230        240 
VFVLWGAYAR KKARLITAPH HVIIESAHPS PLSVTRFMGT RPFSRVNAAL EEAGEAPIDW 


QLPAQVEE

« Hide

References

[1]"Alliance of proteomics and genomics to unravel the specificities of Sahara bacterium Deinococcus deserti."
de Groot A., Dulermo R., Ortet P., Blanchard L., Guerin P., Fernandez B., Vacherie B., Dossat C., Jolivet E., Siguier P., Chandler M., Barakat M., Dedieu A., Barbe V., Heulin T., Sommer S., Achouak W., Armengaud J.
PLoS Genet. 5:E1000434-E1000434(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VCD115 / DSM 17065 / LMG 22923.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001114 Genomic DNA. Translation: ACO44883.1.
RefSeqYP_002784637.1. NC_012526.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING546414.Deide_00830.

Proteomic databases

PaxDbC1CXS7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO44883; ACO44883; Deide_00830.
GeneID7739194.
KEGGddr:Deide_00830.
PATRIC21613528. VBIDeiDes121019_0086.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0692.
HOGENOMHOG000229528.
KOK03648.
OMAAGKEIYP.
ProtClustDBPRK05254.

Enzyme and pathway databases

BioCycDDES546414:GHOM-956-MONOMER.

Family and domain databases

Gene3D3.40.470.10. 1 hit.
HAMAPMF_00148. UDG.
InterProIPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERPTHR11264. PTHR11264. 1 hit.
PfamPF03167. UDG. 1 hit.
[Graphical view]
SMARTSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMSSF52141. UDNA_glycsylseSF. 1 hit.
TIGRFAMsTIGR00628. ung. 1 hit.
PROSITEPS00130. U_DNA_GLYCOSYLASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUNG_DEIDV
AccessionPrimary (citable) accession number: C1CXS7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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